1-(4-amino-3-iodobenzyl)-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-(4-amino-3-iodobenzyl)-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:180623-55-6
Molecular Formula:C₂₀H₂₀F₃IN₂O₃
Molecular Weight:520.29
Hs Code.:

Synonyms:1-(4-amino-3-iodobenzyl)-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 1-(4-amino-3-iodobenzyl)-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 1-(4-amino-3-iodobenzyl)-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

There total 8 articles about 1-(4-amino-3-iodobenzyl)-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 180623-53-4
1-(4-Aminobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

: 180623-55-6
1-(4-amino-3-iodobenzyl)-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate; In methanol; dichloromethane;
DOI:10.1021/jm960208o

Reference yield: 44.0%

: 180623-53-4
1-(4-Aminobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

: 180623-55-6
1-(4-amino-3-iodobenzyl)-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 180623-57-8
1-(4-Amino-3,5-diiodobenzyl)-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: 1-(4-Aminobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline; With N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate; In methanol; dichloromethane; at 20 ℃;

With N,N,N-trimethylbenzenemethanaminium dichloroiodate; In methanol; dichloromethane;

Reference yield:

: 10268-26-5
1,2,3,4-tetrahydro-6,7-dimethoxy-1-[(4-nitrophenyl)methyl]isoquinoline

: 180623-55-6
1-(4-amino-3-iodobenzyl)-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / tetrahydrofuran / Ambient temperature

2: 87 percent / H₂ / 5percent Pd/C / ethyl acetate / 2 h / 3102.9 Torr

3: 84 percent / benzyltrimethylammonium dichloroiodate, CaCO₃ / methanol; CH₂Cl₂

With hydrogen; N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm960208o