5-[2-(4-bromo-phenyl)-2-methyl-[1,3]dithian-4-yl]-pentanoic acid

Base Information

• Chemical Name: 5-[2-(4-bromo-phenyl)-2-methyl-[1,3]dithian-4-yl]-pentanoic acid
• CAS No.: 220820-74-6
• Molecular Formula: C₁₆H₂₁BrO₂S₂
• Molecular Weight: 389.378
• Mol file: 220820-74-6.mol

Synonyms:5-[2-(4-bromo-phenyl)-2-methyl-[1,3]dithian-4-yl]-pentanoic acid

Chemical Property of 5-[2-(4-bromo-phenyl)-2-methyl-[1,3]dithian-4-yl]-pentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[2-(4-bromo-phenyl)-2-methyl-[1,3]dithian-4-yl]-pentanoic acid

There total 4 articles about 5-[2-(4-bromo-phenyl)-2-methyl-[1,3]dithian-4-yl]-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-[(2R,4R)-2-(4-Bromo-phenyl)-2-methyl-[1,3]dithian-4-yl]-pentanoic acid methyl ester → 5-[2-(4-bromo-phenyl)-2-methyl-[1,3]dithian-4-yl]-pentanoic acid (220820-74-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; for 24h;

DOI:10.1016/S0040-4039(98)02580-5

Reference yield:

1,2-dithiolane-3-pentanoic acid methyl ester (46236-19-5) → 5-[2-(4-bromo-phenyl)-2-methyl-[1,3]dithian-4-yl]-pentanoic acid (220820-74-6)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄ / methanol / 1.5 h / Ambient temperature

2: 67 percent / BF₃*Et₂O / CH₂Cl₂ / 120 h / Ambient temperature

3: 100 percent / NaOH / H₂O; tetrahydrofuran / 24 h

With sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1016/S0040-4039(98)02580-5

Reference yield:

6,8-dimercaptooctanoic acid methyl ester (50628-93-8) → 5-[2-(4-bromo-phenyl)-2-methyl-[1,3]dithian-4-yl]-pentanoic acid (220820-74-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / BF₃*Et₂O / CH₂Cl₂ / 120 h / Ambient temperature

2: 100 percent / NaOH / H₂O; tetrahydrofuran / 24 h

With sodium hydroxide; boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/S0040-4039(98)02580-5

upstream raw materials:

1,2-dithiolane-3-pentanoic acid methyl ester

6,8-dimercaptooctanoic acid methyl ester

Thioctic acid

Downstream raw materials:

4'-(4-chlorophenyl)acetophenone

1-(4'-methoxy-biphenyl-4-yl)-ethanone

biphenyl-4-acetaldehyde