3-chloro-4,5-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

Base Information

Chemical Name:3-chloro-4,5-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide
CAS No.:1338708-61-4
Molecular Formula:C₂₉H₃₃ClN₂O₅
Molecular Weight:525.044
Hs Code.:

Synonyms:3-chloro-4,5-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

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Chemical Property of 3-chloro-4,5-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

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Technology Process of 3-chloro-4,5-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

There total 5 articles about 3-chloro-4,5-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1338708-61-4
3-chloro-4,5-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h; Cooling with ice;

In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield: 79.0%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 3-chloro-4,5-bis((4-methoxybenzyl)oxy)benzoic acid

: 1338708-61-4
3-chloro-4,5-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.ejmech.2018.06.014

Reference yield:

: 132496-77-6
methyl 3,4-dihydroxy-5-chlorobenzoate

: 1338708-61-4
3-chloro-4,5-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 3.5 h / 50 °C / Inert atmosphere

2: sodium hydroxide / tetrahydrofuran; methanol / 1.5 h / Reflux; Inert atmosphere

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2018.06.014