2,5-DIMETHYL-1-[4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE-3-CARBALDEHYDE

Base Information

Chemical Name:2,5-DIMETHYL-1-[4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE-3-CARBALDEHYDE
CAS No.:256529-25-6
Molecular Formula:C₁₄H₁₂F₃NO
Molecular Weight:267.251
Hs Code.:
Mol file:256529-25-6.mol

Synonyms:2,5-dimethyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrrole-3-carbaldehyde

Suppliers and Price of 2,5-DIMETHYL-1-[4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE-3-CARBALDEHYDE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2,5-DIMETHYL-1-[4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE-3-CARBALDEHYDE 95.00%
5G
$ 1114.58

American Custom Chemicals Corporation
2,5-DIMETHYL-1-[4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE-3-CARBALDEHYDE 95.00%
2.5G
$ 932.60

American Custom Chemicals Corporation
2,5-DIMETHYL-1-[4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE-3-CARBALDEHYDE 95.00%
1G
$ 692.46

Total 4 raw suppliers

Chemical Property of 2,5-DIMETHYL-1-[4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE-3-CARBALDEHYDE

Chemical Property:

Boiling Point:343.0±42.0 °C(Predicted)
PKA:-6.04±0.70(Predicted)
Density:1.20±0.1 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

2,5-DIMETHYL-1-[4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE-3-CARBALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,5-DIMETHYL-1-[4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE-3-CARBALDEHYDE

There total 3 articles about 2,5-DIMETHYL-1-[4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE-3-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 570-05-8
2,5-dimethyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrrole

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 256529-25-6
2,5-dimethyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrrole-3-carbaldehyde

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; at 20 ℃; for 0.25h; Inert atmosphere;

2,5-dimethyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrrole; at 100 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm400009c

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 256529-25-6
2,5-dimethyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrrole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid; silica gel / neat (no solvent) / 180 °C / Microwave irradiation

2.1: trichlorophosphate / 0.25 h / 20 °C / Inert atmosphere

2.2: 3 h / 100 °C / Inert atmosphere

With silica gel; toluene-4-sulfonic acid; trichlorophosphate; In neat (no solvent); 1.1: |Paal-Knorr Pyrrole Synthesis / 2.2: |Vilsmeier-Haack Formylation;
DOI:10.1021/jm400009c

Reference yield:

: 110-13-4
2,5-hexanedione

: 256529-25-6
2,5-dimethyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrrole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid; silica gel / neat (no solvent) / 180 °C / Microwave irradiation

2.1: trichlorophosphate / 0.25 h / 20 °C / Inert atmosphere

2.2: 3 h / 100 °C / Inert atmosphere

With silica gel; toluene-4-sulfonic acid; trichlorophosphate; In neat (no solvent); 1.1: |Paal-Knorr Pyrrole Synthesis / 2.2: |Vilsmeier-Haack Formylation;
DOI:10.1021/jm400009c