3-(2-Ethoxycarbonyl-1-hydroxyethyl)-2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyridine

Base Information

Chemical Name:3-(2-Ethoxycarbonyl-1-hydroxyethyl)-2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyridine
CAS No.:151323-13-6
Molecular Formula:C₂₇H₃₀N₆O₃
Molecular Weight:486.574
Hs Code.:

Synonyms:3-(2-Ethoxycarbonyl-1-hydroxyethyl)-2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyridine

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Chemical Property of 3-(2-Ethoxycarbonyl-1-hydroxyethyl)-2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyridine

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Technology Process of 3-(2-Ethoxycarbonyl-1-hydroxyethyl)-2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyridine

There total 9 articles about 3-(2-Ethoxycarbonyl-1-hydroxyethyl)-2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 157361-25-6
3-(2-Ethoxycarbonyl-1-hydroxyethyl)-2-{N-propyl-N-[(2'-[N-triphenylmethyl-1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyridine

: 151323-13-6
3-(2-Ethoxycarbonyl-1-hydroxyethyl)-2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyridine

Guidance literature:: In tetrahydrofuran; chloroform; water; acetic acid; toluene;

Reference yield:

: 151323-68-1
3-<2-(ethoxycarbonyl)-1-hydroxyethyl>-2-biphenyl-4-yl>methyl>amino>pyridine

: 151323-13-6
3-Hydroxy-3-(2-{propyl-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-pyridin-3-yl)-propionic acid ethyl ester

Guidance literature:: With formic acid; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm00070a012

Reference yield:

: 49609-84-9
2-Chloronicotinoyl chloride

: 151323-13-6
3-Hydroxy-3-(2-{propyl-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-pyridin-3-yl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 0.33 h / Heating

2: 68 percent / ethanol / 6 h / 100 °C

3: 1.) 1,3-dimethyl-3,4,5,6-tetrahydro-2-pyrimidinone, LiN(TMS)2 / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 90 min

4: 95 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

5: 96 percent / MnO₂ / 20 h / Ambient temperature

6: 1.) LDA / 1.) hexane, THF, 0 deg C, 20 min, 2.) hexane, THF, -78 deg C, 45 min

7: 88percent aq. HCOOH / CH₂Cl₂ / 2 h / Ambient temperature

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; manganese(IV) oxide; lithium aluminium tetrahydride; formic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00070a012