6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinic acid

Base Information

Chemical Name:6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinic acid
CAS No.:1428552-60-6
Molecular Formula:C₁₉H₁₆F₃N₅O₄
Molecular Weight:435.362
Hs Code.:

Synonyms:6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinic acid

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Chemical Property of 6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinic acid

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Technology Process of 6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinic acid

There total 2 articles about 6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 6-(6-(4-(phosphonooxy)benzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinate

: 1428552-60-6
6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinic acid

Guidance literature:: With potassium carbonate; In methanol; water; at 20 ℃; for 72h;

Reference yield:

: 1428552-58-2
methyl 6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinate

: 1428552-60-6
6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus trichloride / ethyl acetate / 0.5 h

2: potassium carbonate / methanol; water / 72 h / 20 °C

With potassium carbonate; phosphorus trichloride; In methanol; water; ethyl acetate;

Reference yield:

: 1428552-60-6
6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinic acid

: 292606-35-0
N-tert-butyloxycarbonyl-2,2-dimethyl-1,3-propanediamine

: 1428552-61-7
tert-butyl 3-(6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinamido)-2,2-dimethylpropylcarbamate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 16h;