methyl 6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinate

Base Information

Chemical Name:methyl 6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinate
CAS No.:1428552-58-2
Molecular Formula:C₂₀H₁₈F₃N₅O₄
Molecular Weight:449.389
Hs Code.:

Synonyms:methyl 6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinate

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Chemical Property of methyl 6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinate

Chemical Property:

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Technology Process of methyl 6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinate

There total 1 articles about methyl 6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-89-8
2,2,2-trifluoroethanol

: 1428552-55-9
2-(6-(4-hydroxybenzylamino)-2-(methylsulfonyl)pyrimidin-4-ylamino)-5-(methoxycarbonyl)pyridine-1-oxide

: 1428552-56-0
methyl 6-(6-(4-hydroxybenzylamino)-2-(methylsulfonyl)pyrimidin-4-ylamino)nicotinate

: 1428552-57-1
2-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)-5-(methoxycarbonyl)pyridine-1-oxide

: 1428552-58-2
methyl 6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 72h;

Reference yield:

: 1428552-57-1
2-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)-5-(methoxycarbonyl)pyridine-1-oxide

: 1428552-58-2
methyl 6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinate

: methyl 6-(6-(4-(phosphonooxy)benzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinate

Guidance literature:: With phosphorus trichloride; In ethyl acetate; for 0.5h;

Reference yield:

: 1428552-58-2
methyl 6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinate

: 1428552-60-6
6-(6-(4-hydroxybenzylamino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-ylamino)nicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus trichloride / ethyl acetate / 0.5 h

2: potassium carbonate / methanol; water / 72 h / 20 °C

With potassium carbonate; phosphorus trichloride; In methanol; water; ethyl acetate;