carbonic acid ethyl ester 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester

Base Information

Chemical Name:carbonic acid ethyl ester 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester
CAS No.:1229022-23-4
Molecular Formula:C₂₂H₃₀N₂O₅
Molecular Weight:402.491
Hs Code.:

Synonyms:carbonic acid ethyl ester 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester

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Chemical Property of carbonic acid ethyl ester 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester

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Technology Process of carbonic acid ethyl ester 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester

There total 8 articles about carbonic acid ethyl ester 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1229022-24-5
4-hydroxy-8-methoxy-1-methyl-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-2-one

: 541-41-3
chloroformic acid ethyl ester

: 1229022-23-4
carbonic acid ethyl ester 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 0 ℃;

Reference yield:

: 1145784-38-8
4-hydroxy-8-methoxy-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-2-one

: 1229022-23-4
carbonic acid ethyl ester 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 1 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: hydrogen / 5%-palladium/activated carbon / water; methanol / 22 h / 36 °C / 3000.3 Torr

4.1: triethylamine / dmap / tetrahydrofuran / 1 h / 0 °C

With hydrogen; potassium carbonate; triethylamine; lithium hexamethyldisilazane; dmap; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; water; acetone;

Reference yield:

: 1229022-30-3
1-methoxy-4-methylamino-piperidine-4-carbonitrile

: 1229022-23-4
carbonic acid ethyl ester 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dmap / tetrahydrofuran / 4.5 h / 0 - 20 °C

2.1: sulfuric acid / 2.25 h / 15 - 20 °C

2.2: pH 5 - 5.5 / Cooling with ice

3.1: sodium methylate / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

3.2: pH 5 - 6 / Cooling with ice

4.1: triethylamine / dmap / tetrahydrofuran / 1 h / 0 °C

With sulfuric acid; sodium methylate; triethylamine; dmap; In tetrahydrofuran; N,N-dimethyl-formamide;