(4''S,4''S)-1-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxy]-4-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxymethyl]-2,3,5,6-tetrafluorobenzene

Base Information

Chemical Name:(4''S,4''S)-1-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxy]-4-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxymethyl]-2,3,5,6-tetrafluorobenzene
CAS No.:1301708-35-9
Molecular Formula:C₆₃H₆₄F₄N₂O₄P₂
Molecular Weight:1051.15
Hs Code.:

(4''S,4''S)-1-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxy]-4-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxymethyl]-2,3,5,6-tetrafluorobenzene

Synonyms:(4''S,4''S)-1-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxy]-4-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxymethyl]-2,3,5,6-tetrafluorobenzene

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Chemical Property of (4''S,4''S)-1-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxy]-4-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxymethyl]-2,3,5,6-tetrafluorobenzene

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Technology Process of (4''S,4''S)-1-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxy]-4-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxymethyl]-2,3,5,6-tetrafluorobenzene

There total 6 articles about (4''S,4''S)-1-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxy]-4-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxymethyl]-2,3,5,6-tetrafluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1301708-18-8
(4S)-4-tert-butyl-2-[4'-hydroxymethyl-2'-(di-ortho-tolylphosphanyl)-phenyl]-4,5-dihydrooxazole

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 1301708-35-9
(4''S,4''S)-1-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxy]-4-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxymethyl]-2,3,5,6-tetrafluorobenzene

Guidance literature:: (4S)-4-tert-butyl-2-[4'-hydroxymethyl-2'-(di-ortho-tolylphosphanyl)-phenyl]-4,5-dihydrooxazole; With potassium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

(bromomethyl)pentafluorobenzene; In tetrahydrofuran; at 20 ℃; for 15h; chemoselective reaction; Inert atmosphere;
DOI:10.1002/chem.201003314

Reference yield:

: 874-89-5
4-Cyanobenzyl alcohol

: 1301708-35-9
(4''S,4''S)-1-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxy]-4-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxymethyl]-2,3,5,6-tetrafluorobenzene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / dichloromethane / 23.25 h / 0 - 20 °C / Inert atmosphere

2.1: zinc(II) chloride / chlorobenzene / 71 h / Inert atmosphere; Reflux

3.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / cyclohexane; pentane / 1.92 h / -78 - 0 °C / Inert atmosphere

3.2: 15 h / 0 - 20 °C / Inert atmosphere

4.1: tetra-n-butylammoniumfluoride trihydrate / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere

5.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

5.2: 15 h / 20 °C / Inert atmosphere

With 1H-imidazole; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; potassium hydride; tetra-n-butylammoniumfluoride trihydrate; zinc(II) chloride; In tetrahydrofuran; dichloromethane; cyclohexane; chlorobenzene; pentane;
DOI:10.1002/chem.201003314

Reference yield:

: 1301708-11-1
(4S)-4-tert-butyl-2-[4-(tert-butyldimethylsilanyloxymethyl)-phenyl]-4,5-dihydrooxazole

: 1301708-35-9
(4''S,4''S)-1-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxy]-4-[4'-(4''-tert-butyl-4'',5''-dihydrooxazol-2-yl)-3'-(di-ortho-tolylphosphanyl)-benzyloxymethyl]-2,3,5,6-tetrafluorobenzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / cyclohexane; pentane / 1.92 h / -78 - 0 °C / Inert atmosphere

1.2: 15 h / 0 - 20 °C / Inert atmosphere

2.1: tetra-n-butylammoniumfluoride trihydrate / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere

3.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3.2: 15 h / 20 °C / Inert atmosphere

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; potassium hydride; tetra-n-butylammoniumfluoride trihydrate; In tetrahydrofuran; cyclohexane; pentane;
DOI:10.1002/chem.201003314