2-{2-Chloro-4-[2-(2-cyclopentyl-4,6-dioxo-tetrahydro-pyran-2-yl)-ethyl]-phenyl}-2-methyl-propionitrile

Base Information

Chemical Name:2-{2-Chloro-4-[2-(2-cyclopentyl-4,6-dioxo-tetrahydro-pyran-2-yl)-ethyl]-phenyl}-2-methyl-propionitrile
CAS No.:749929-85-9
Molecular Formula:C₂₂H₂₆ClNO₃
Molecular Weight:387.906
Hs Code.:

Synonyms:2-{2-Chloro-4-[2-(2-cyclopentyl-4,6-dioxo-tetrahydro-pyran-2-yl)-ethyl]-phenyl}-2-methyl-propionitrile

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Chemical Property of 2-{2-Chloro-4-[2-(2-cyclopentyl-4,6-dioxo-tetrahydro-pyran-2-yl)-ethyl]-phenyl}-2-methyl-propionitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-{2-Chloro-4-[2-(2-cyclopentyl-4,6-dioxo-tetrahydro-pyran-2-yl)-ethyl]-phenyl}-2-methyl-propionitrile

There total 6 articles about 2-{2-Chloro-4-[2-(2-cyclopentyl-4,6-dioxo-tetrahydro-pyran-2-yl)-ethyl]-phenyl}-2-methyl-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 945619-24-9
C₂₅H₃₂ClNO₄

: 749929-85-9
2-{2-Chloro-4-[2-(2-cyclopentyl-4,6-dioxo-tetrahydro-pyran-2-yl)-ethyl]-phenyl}-2-methyl-propionitrile

Guidance literature:: With potassium carbonate; In methanol; at 45 ℃;
DOI:10.1021/jm0704447

Reference yield:

: 612062-71-2
6-(2-cyclopentyl-2-hydroxy-4-trimethylsilanyl-but-3-ynyl)-2,2-dimethyl[1,3]dioxin-4-one

: 749929-85-9
2-{2-Chloro-4-[2-(2-cyclopentyl-4,6-dioxo-tetrahydro-pyran-2-yl)-ethyl]-phenyl}-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 3.6 g / CsF / methanol / 25 °C

2: diisopropylamine / bis(triphenylphosphine)palladium (II) dichloride; CuI / dimethylformamide / 90 °C

3: H₂ / Pd(OH)2/C / ethanol / 6 h / 25 °C

4: K₂CO₃ / methanol / 45 °C

With hydrogen; potassium carbonate; diisopropylamine; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; palladium dihydroxide; copper(l) iodide; In methanol; ethanol; N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1021/jm0704447

Reference yield:

: 945619-17-0
C₂₅H₂₈ClNO₄

: 749929-85-9
2-{2-Chloro-4-[2-(2-cyclopentyl-4,6-dioxo-tetrahydro-pyran-2-yl)-ethyl]-phenyl}-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd(OH)2/C / ethanol / 6 h / 25 °C

2: K₂CO₃ / methanol / 45 °C

With hydrogen; potassium carbonate; palladium dihydroxide; In methanol; ethanol;
DOI:10.1021/jm0704447