2-[2-chloro-4-(2-{2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)phenyl]-2-methylpropanenitrile

Base Information

Chemical Name:2-[2-chloro-4-(2-{2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)phenyl]-2-methylpropanenitrile
CAS No.:749929-84-8
Molecular Formula:C₃₀H₃₄ClN₅O₃
Molecular Weight:548.085
Hs Code.:

2-[2-chloro-4-(2-{2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)phenyl]-2-methylpropanenitrile

Synonyms:2-[2-chloro-4-(2-{2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)phenyl]-2-methylpropanenitrile

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Chemical Property of 2-[2-chloro-4-(2-{2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)phenyl]-2-methylpropanenitrile

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Technology Process of 2-[2-chloro-4-(2-{2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)phenyl]-2-methylpropanenitrile

There total 7 articles about 2-[2-chloro-4-(2-{2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)phenyl]-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55293-96-4
5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carbaldehyde

: 749929-85-9
2-{2-Chloro-4-[2-(2-cyclopentyl-4,6-dioxo-tetrahydro-pyran-2-yl)-ethyl]-phenyl}-2-methyl-propionitrile

: 749929-84-8
2-[2-chloro-4-(2-{2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)phenyl]-2-methylpropanenitrile

Guidance literature:: With dimethylsulfide borane complex; In methanol; at 25 ℃;
DOI:10.1021/jm0704447

Reference yield:

: 612062-71-2
6-(2-cyclopentyl-2-hydroxy-4-trimethylsilanyl-but-3-ynyl)-2,2-dimethyl[1,3]dioxin-4-one

: 749929-84-8
2-[2-chloro-4-(2-{2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)phenyl]-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 3.6 g / CsF / methanol / 25 °C

2: diisopropylamine / bis(triphenylphosphine)palladium (II) dichloride; CuI / dimethylformamide / 90 °C

3: H₂ / Pd(OH)2/C / ethanol / 6 h / 25 °C

4: K₂CO₃ / methanol / 45 °C

5: BH₃*SMe₂ / methanol / 25 °C

With dimethylsulfide borane complex; hydrogen; potassium carbonate; diisopropylamine; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; palladium dihydroxide; copper(l) iodide; In methanol; ethanol; N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1021/jm0704447

Reference yield:

: 945619-17-0
C₂₅H₂₈ClNO₄

: 749929-84-8
2-[2-chloro-4-(2-{2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)phenyl]-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd(OH)2/C / ethanol / 6 h / 25 °C

2: K₂CO₃ / methanol / 45 °C

3: BH₃*SMe₂ / methanol / 25 °C

With dimethylsulfide borane complex; hydrogen; potassium carbonate; palladium dihydroxide; In methanol; ethanol;
DOI:10.1021/jm0704447