5-benzyl-7-methoxy-1,3-diphenyl-3a,4,5,9a-tetrahydro-1H-pyrazolo[4,3-c]quinoline

Base Information

Chemical Name:5-benzyl-7-methoxy-1,3-diphenyl-3a,4,5,9a-tetrahydro-1H-pyrazolo[4,3-c]quinoline
CAS No.:907999-21-7
Molecular Formula:C₃₀H₂₇N₃O
Molecular Weight:445.564
Hs Code.:

Synonyms:5-benzyl-7-methoxy-1,3-diphenyl-3a,4,5,9a-tetrahydro-1H-pyrazolo[4,3-c]quinoline

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Chemical Property of 5-benzyl-7-methoxy-1,3-diphenyl-3a,4,5,9a-tetrahydro-1H-pyrazolo[4,3-c]quinoline

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Technology Process of 5-benzyl-7-methoxy-1,3-diphenyl-3a,4,5,9a-tetrahydro-1H-pyrazolo[4,3-c]quinoline

There total 4 articles about 5-benzyl-7-methoxy-1,3-diphenyl-3a,4,5,9a-tetrahydro-1H-pyrazolo[4,3-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 613-90-1
benzoyl cyanide

: 3954-53-8
1-benzyl-7-methoxy-2,3-dihydro-1H-quinolin-4-one

: 59-88-1
phenylhydrazine hydrochloride

: 907999-19-3
5-benzyl-7-methoxy-2,3-diphenyl-3,3a,4,5-tetrahydro-2H-pyrazolo[4,3-c]quinoline

: 907999-21-7
5-benzyl-7-methoxy-1,3-diphenyl-3a,4,5,9a-tetrahydro-1H-pyrazolo[4,3-c]quinoline

Guidance literature:: 1-benzyl-7-methoxy-2,3-dihydro-1H-quinolin-4-one; With lithium hexamethyldisilazane; In tetrahydrofuran; for 0.25h;

benzoyl cyanide; In tetrahydrofuran; for 0.5h;

phenylhydrazine hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; Further stages.; Heating;
DOI:10.1055/s-2006-926466

Reference yield:

: 879-56-1
7-Methoxy-2,3-dihydro-1H-quinolin-4-one

: 907999-21-7
5-benzyl-7-methoxy-1,3-diphenyl-3a,4,5,9a-tetrahydro-1H-pyrazolo[4,3-c]quinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: 88 percent / K₂CO₃ / dimethylformamide / 60 °C

2.1: LHMDS / tetrahydrofuran / 0.25 h

2.2: tetrahydrofuran / 0.5 h

2.3: 35 percent / tetrahydrofuran; dimethylformamide / Heating

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1055/s-2006-926466

Reference yield:

: 3334-67-6
3-((3-methoxyphenyl)amino)propanoic acid

: 907999-21-7
5-benzyl-7-methoxy-1,3-diphenyl-3a,4,5,9a-tetrahydro-1H-pyrazolo[4,3-c]quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: 77 percent / PPA / 90 °C

2.1: 88 percent / K₂CO₃ / dimethylformamide / 60 °C

3.1: LHMDS / tetrahydrofuran / 0.25 h

3.2: tetrahydrofuran / 0.5 h

3.3: 35 percent / tetrahydrofuran; dimethylformamide / Heating

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1055/s-2006-926466