3334-67-6Relevant academic research and scientific papers
2,3-dihydro-1H-quinoline-4-ketone thiosemicarbazone derivatives as well as preparation method and application thereof
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Paragraph 0076-0079; 0198-0201, (2019/04/04)
The invention discloses 2,3-dihydro-1H-quinoline-4-ketone thiosemicarbazone derivatives as well as a preparation method and application thereof. The structural formula of the derivatives is as shown in a formula (I): (the formula is as shown in the description), wherein R1 is halogen, alkyl or alkoxy; R2 is hydrogen, halogen or alkoxy; R3 is hydrogen or halogen; R4 is hydrogen or halogen; X is hydrogen, acetyl or nitryl; and Y is hydrogen or phenyl. The derivatives can obviously inhibit proliferation of tumor cells, and has significant inhibition effect on multiple cancer cell strains such asbreast cancer cells, melanoma cells and prostatic cancer cells; and the anti-tumor activity is obviously better than that of a broad-spectrum anti-cancer medicine cis-platinum. In addition, the preparation process of the derivatives is simple, the conditions are mild, the sources of the raw materials are rich, the production cost is low, and potential medicinal value and good application prospectin the aspect of preparing a novel anti-tumor medicine are achieved.
HETEROCYCLIC ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF
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Paragraph 00221; 00229, (2019/07/13)
The present application is directed to compounds of Formula (I): compounds of Formula (II): compounds of Formula (III): and compounds of Formula (IV): compositions comprising these compounds and their uses, for example as medicaments and /or diagnostics.
INHIBITORS OF HEPATITIS C VIRUS
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Page/Page column 112, (2012/05/19)
A class of compounds that inhibit Hepatitis C Virus (HCV) is disclosed, along with compositions containing the compound, and methods of using the composition for treating individuals infected with HCV.
Synthesis of novel conformationally constrained pyrazolo[4,3-c]quinoline derivatives as potential ligands for the estrogen receptor
Kasiotis, Konstantinos M.,Fokialakis, Nikolas,Haroutounian, Serkos A.
, p. 1791 - 1802 (2008/01/27)
The preparation of three novel classes of pyrazolo[4,3-c]quinoline derivatives is reported. The easily accessible 2,3-dihydro-1H-quinolin-4-ones were used as the starting materials and were functionalized with three different acylating agents affording th
Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)- 2H-pyrano[3,2-g]quinolin-2-one
Edwards, James P.,Higuchi, Robert I.,Winn, David T.,Pooley, Charlotte L. F.,Caferro, Thomas R.,Hamann, Lawrence G.,Zhi, Lin,Marschke, Keith B.,Goldman, Mark E.,Jones, Todd K.
, p. 1003 - 1008 (2007/10/03)
A series of 2H-pyrano[3,2-g]quinolin-2-ones was prepared and tested for the ability to modulate the transcriptional activity of the human androgen receptor (hAR). The parent compound, 4-(trifluoromethyl)-2H-pyrano[3,2- g]quinolin-2-one, displayed moderate
Steroid receptor modulator compounds and methods
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, (2008/06/13)
Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.
