2-(6-(2-(1-hydroxy-7-phenylheptyl)oxazol-5-yl)pyridin-3-yl)acetonitrile

Base Information

Chemical Name:2-(6-(2-(1-hydroxy-7-phenylheptyl)oxazol-5-yl)pyridin-3-yl)acetonitrile
CAS No.:1429771-05-0
Molecular Formula:C₂₃H₂₅N₃O₂
Molecular Weight:375.47
Hs Code.:

Synonyms:2-(6-(2-(1-hydroxy-7-phenylheptyl)oxazol-5-yl)pyridin-3-yl)acetonitrile

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Chemical Property of 2-(6-(2-(1-hydroxy-7-phenylheptyl)oxazol-5-yl)pyridin-3-yl)acetonitrile

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Technology Process of 2-(6-(2-(1-hydroxy-7-phenylheptyl)oxazol-5-yl)pyridin-3-yl)acetonitrile

There total 6 articles about 2-(6-(2-(1-hydroxy-7-phenylheptyl)oxazol-5-yl)pyridin-3-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1429771-04-9
2-(6-(2-(1-((tert-butyldimethylsilyl)oxy)-7-phenylheptyl)oxazol-5-7yl)pyridin-3-yl)acetonitrile

: 1429771-05-0
2-(6-(2-(1-hydroxy-7-phenylheptyl)oxazol-5-yl)pyridin-3-yl)acetonitrile

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ja4014997

Reference yield: 84.0%

: 1429771-02-7
2-(6-(2-(7-phenylheptanoyl)-1,3-oxazol-5-yl)pyridin-3-yl)acetonitrile

: 1429771-05-0
2-(6-(2-(1-hydroxy-7-phenylheptyl)oxazol-5-yl)pyridin-3-yl)acetonitrile

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 1h;
DOI:10.1021/ja4014997

Reference yield:

: 70258-18-3
2-chloro-5-(chloromethyl)pyridine

: 1429771-05-0
2-(6-(2-(1-hydroxy-7-phenylheptyl)oxazol-5-yl)pyridin-3-yl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 24 h / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 16 h / Reflux; Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 2: |Stille Cross Coupling;
DOI:10.1021/jm401820q