2-(6-(2-(1-((tert-butyldimethylsilyl)oxy)-7-phenylheptyl)oxazol-5-7yl)pyridin-3-yl)acetonitrile

Base Information

Chemical Name:2-(6-(2-(1-((tert-butyldimethylsilyl)oxy)-7-phenylheptyl)oxazol-5-7yl)pyridin-3-yl)acetonitrile
CAS No.:1429771-04-9
Molecular Formula:C₂₉H₃₉N₃O₂Si
Molecular Weight:489.733
Hs Code.:

Synonyms:2-(6-(2-(1-((tert-butyldimethylsilyl)oxy)-7-phenylheptyl)oxazol-5-7yl)pyridin-3-yl)acetonitrile

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Chemical Property of 2-(6-(2-(1-((tert-butyldimethylsilyl)oxy)-7-phenylheptyl)oxazol-5-7yl)pyridin-3-yl)acetonitrile

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Technology Process of 2-(6-(2-(1-((tert-butyldimethylsilyl)oxy)-7-phenylheptyl)oxazol-5-7yl)pyridin-3-yl)acetonitrile

There total 3 articles about 2-(6-(2-(1-((tert-butyldimethylsilyl)oxy)-7-phenylheptyl)oxazol-5-7yl)pyridin-3-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70258-18-3
2-chloro-5-(chloromethyl)pyridine

: 1429771-04-9
2-(6-(2-(1-((tert-butyldimethylsilyl)oxy)-7-phenylheptyl)oxazol-5-7yl)pyridin-3-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 24 h / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 16 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; N,N-dimethyl-formamide; 2: |Stille Cross Coupling;
DOI:10.1021/jm401820q

Reference yield:

: 73781-91-6
6-Chloronicotinic acid methyl ester

: 1429771-04-9
2-(6-(2-(1-((tert-butyldimethylsilyl)oxy)-7-phenylheptyl)oxazol-5-7yl)pyridin-3-yl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2: thionyl chloride / dichloromethane / 2 h / Inert atmosphere

3: N,N-dimethyl-formamide / 24 h / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 16 h / Reflux; Inert atmosphere

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 4: |Stille Cross Coupling;
DOI:10.1021/jm401820q

Reference yield:

: 21543-49-7
2-Chloro-5-hydroxymethylpyridine

: 1429771-04-9
2-(6-(2-(1-((tert-butyldimethylsilyl)oxy)-7-phenylheptyl)oxazol-5-7yl)pyridin-3-yl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / dichloromethane / 2 h / Inert atmosphere

2: N,N-dimethyl-formamide / 24 h / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 16 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 3: |Stille Cross Coupling;
DOI:10.1021/jm401820q