1-bromo-3-(2 (S)-methoxy-3-phenylpropyl)benzene

Base Information

Chemical Name:1-bromo-3-(2 (S)-methoxy-3-phenylpropyl)benzene
CAS No.:1222139-36-7
Molecular Formula:C₁₆H₁₇BrO
Molecular Weight:305.214
Hs Code.:

Synonyms:1-bromo-3-(2 (S)-methoxy-3-phenylpropyl)benzene

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Chemical Property of 1-bromo-3-(2 (S)-methoxy-3-phenylpropyl)benzene

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Technology Process of 1-bromo-3-(2 (S)-methoxy-3-phenylpropyl)benzene

There total 7 articles about 1-bromo-3-(2 (S)-methoxy-3-phenylpropyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1222139-25-4
1-(3-bromophenyl)-3-phenyl-2(S)-propanol

: 74-88-4
methyl iodide

: 1222139-36-7
1-bromo-3-(2 (S)-methoxy-3-phenylpropyl)benzene

Guidance literature:: 1-(3-bromophenyl)-3-phenyl-2(S)-propanol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

methyl iodide; In tetrahydrofuran; MEneral oil; at 20 ℃;

Reference yield:

: 91420-74-5
(S)-(2,3-epoxypropyl)benzene

: 1222139-36-7
1-bromo-3-(2 (S)-methoxy-3-phenylpropyl)benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran; hexane / 3 h / -40 °C / Inert atmosphere

1.2: 2 h / -20 - -5 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil; Petroleum ether / 0.5 h / 0 - 20 °C

With isopropylmagnesium chloride; sodium hydride; In tetrahydrofuran; hexane; mineral oil; Petroleum ether;

Reference yield:

: 20312-36-1
L-3-phenyllactic acid

: 1222139-36-7
1-bromo-3-(2 (S)-methoxy-3-phenylpropyl)benzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

2.1: hydrogenchloride; triethylamine; p-toluenesulfonyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 0 °C / Inert atmosphere

3.1: isopropylmagnesium chloride / tetrahydrofuran; hexane / 3 h / -40 °C / Inert atmosphere

3.2: 2 h / -20 - -5 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil; Petroleum ether / 0.5 h / 0 - 20 °C

With hydrogenchloride; borane-THF; isopropylmagnesium chloride; sodium hydride; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; hexane; dichloromethane; mineral oil; Petroleum ether;