3-[(2-methyl-4-nitroindol-3-yl)-o-(trifluoromethyl)phenylmethyl]-4H-chromen-4-one

Base Information

• Chemical Name: 3-[(2-methyl-4-nitroindol-3-yl)-o-(trifluoromethyl)phenylmethyl]-4H-chromen-4-one
• CAS No.: 944055-61-2
• Molecular Formula: C₂₆H₁₇F₃N₂O₄
• Molecular Weight: 478.427

Synonyms:3-[(2-methyl-4-nitroindol-3-yl)-o-(trifluoromethyl)phenylmethyl]-4H-chromen-4-one

Chemical Property of 3-[(2-methyl-4-nitroindol-3-yl)-o-(trifluoromethyl)phenylmethyl]-4H-chromen-4-one

Chemical Property:

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Technology Process of 3-[(2-methyl-4-nitroindol-3-yl)-o-(trifluoromethyl)phenylmethyl]-4H-chromen-4-one

There total 2 articles about 3-[(2-methyl-4-nitroindol-3-yl)-o-(trifluoromethyl)phenylmethyl]-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-[acetoxy(2-trifluoromethylphenyl)methyl]-4H-chromen-4-one (944055-49-6) + 2-methyl-4-nitro-1H-indole (3484-10-4) → 3-[(2-methyl-4-nitroindol-3-yl)-o-(trifluoromethyl)phenylmethyl]-4H-chromen-4-one (944055-61-2)

Guidance literature:

With silver trifluoromethanesulfonate; In dichloromethane; for 3h; Heating;

DOI:10.1021/ol070878w

Reference yield:

C17H11O3F3 → 3-[(2-methyl-4-nitroindol-3-yl)-o-(trifluoromethyl)phenylmethyl]-4H-chromen-4-one (944055-61-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 1 h

2: 89 percent / AgOTf / CH₂Cl₂ / 3 h / Heating

With pyridine; silver trifluoromethanesulfonate; In dichloromethane;

DOI:10.1021/ol070878w

Reference yield: 72.0%

3-[(2-methyl-4-nitroindol-3-yl)-o-(trifluoromethyl)phenylmethyl]-4H-chromen-4-one (944055-61-2) → 2-methyl-3-[o-(trifluoromethyl)phenyl]-4-(2-hydroxybenzoyl)-3,6-dihydro-1H-azepino[4,3,2-cd]-indole

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; atmospheric pressure;

DOI:10.1021/ol070878w

upstream raw materials:

3-[acetoxy(2-trifluoromethylphenyl)methyl]-4H-chromen-4-one

2-methyl-4-nitro-1H-indole

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