tert-butyl 4-(5-chloro-6-methoxypyridin-3-yl)-3-methylbenzoate

Base Information

• Chemical Name: tert-butyl 4-(5-chloro-6-methoxypyridin-3-yl)-3-methylbenzoate
• CAS No.: 1432055-36-1
• Molecular Formula: C₁₈H₂₀ClNO₃
• Molecular Weight: 333.815
• Mol file: 1432055-36-1.mol

Synonyms:tert-butyl 4-(5-chloro-6-methoxypyridin-3-yl)-3-methylbenzoate

Chemical Property of tert-butyl 4-(5-chloro-6-methoxypyridin-3-yl)-3-methylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(5-chloro-6-methoxypyridin-3-yl)-3-methylbenzoate

There total 3 articles about tert-butyl 4-(5-chloro-6-methoxypyridin-3-yl)-3-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (1073493-92-1) + 5-bromo-3-chloro-2-methoxypyridine (848366-28-9) → tert-butyl 4-(5-chloro-6-methoxypyridin-3-yl)-3-methylbenzoate (1432055-36-1)

Guidance literature:

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 80 ℃;

Reference yield:

4-bromo-3-methylbenzoic acid (7697-28-1) → tert-butyl 4-(5-chloro-6-methoxypyridin-3-yl)-3-methylbenzoate (1432055-36-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap / tert-butyl alcohol / 70 °C

2: potassium acetate; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride / 1,4-dioxane / 125 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / 1,4-dioxane; water / 80 °C

With dmap; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride; potassium acetate; In 1,4-dioxane; water; tert-butyl alcohol; 2: |Miyaura Borylation Reaction;

Reference yield:

tert-butyl 4-bromo-3-methylbenzoate (347174-28-1) → tert-butyl 4-(5-chloro-6-methoxypyridin-3-yl)-3-methylbenzoate (1432055-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium acetate; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride / 1,4-dioxane / 125 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / 1,4-dioxane; water / 80 °C

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride; potassium acetate; In 1,4-dioxane; water; 1: |Miyaura Borylation Reaction;

upstream raw materials:

4-bromo-3-methylbenzoic acid

tert-butyl 4-bromo-3-methylbenzoate

tert-butyl 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

5-bromo-3-chloro-2-methoxypyridine

Downstream raw materials:

tert-butyl 4-{5-[2-{(1R,5S,7aS)-1-[3,5-bis(trifluoromethyl)phenyl]-3-oxotetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-5-yl}-4-(trifluoromethyl)phenyl]-6-methoxypyridin-3-yl}-3-methylbenzoate

4-{5-[2-{(1R,5S,7aS)-1-[3,5-bis(trifluoromethyl)phenyl]-3-oxotetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-5-yl}-4-(trifluoromethyl)phenyl]-6-methoxypyridin-3-yl}-3-methylbenzoic acid

tert-butyl 4-[6-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]-3-methylbenzoate