7-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-5-ethyl-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

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Chemical Name:7-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-5-ethyl-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one
CAS No.:1027228-66-5
Molecular Formula:C₂₆H₃₂N₄O₂Si
Molecular Weight:460.651
Hs Code.:

Synonyms:7-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-5-ethyl-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

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Chemical Property of 7-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-5-ethyl-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

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Technology Process of 7-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-5-ethyl-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

There total 8 articles about 7-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-5-ethyl-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 4-(tributylstannyl)phenol tertbutyldimethylsilyl ether

: 135795-50-5
5,11-dihydro-11-ethyl-5-methyl-2-<<(trifluoromethyl)-sulfonyl>oxy>-6H-dipyrido<3,2-b:2',3'-e><1,4>diazepin-6-one

: 1027228-66-5
7-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-5-ethyl-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; In 1,4-dioxane; for 1.5h; Heating;
DOI:10.1021/jm00024a010

Reference yield:

: 6628-77-9
6-methoxy-pyridin-3-ylamine

: 1027228-66-5
7-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-5-ethyl-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Guidance literature:: Multi-step reaction with 8 steps

1: 60 percent / NaOAc, Br₂ / acetic acid / 0.33 h

2: 90 percent / pyridine / CH₂Cl₂ / 0.33 h / Ambient temperature

3: 1.) NaH, DMSO / 1.) 50 deg C, 2.) DMSO, 30 min

4: 76 percent / xylene / 4 h / 150 °C

5: 76 percent / NaH / xylene / 2 h / 150 °C

6: 98 percent / 48percent aq. HBr, AcOH / 0.08 h / Heating

7: 77 percent / diisopropylethylamine / CHCl₃

8: 69 percent / Pd(Ph₃P)4, LiCl / dioxane / 1.5 h / Heating

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; bromine; sodium acetate; sodium hydride; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; lithium chloride; In 1,4-dioxane; dichloromethane; chloroform; acetic acid; xylene;
DOI:10.1021/jm00024a010

Reference yield:

: 135795-46-9
2-bromo-6-methoxy-pyridin-3-ylamine

: 1027228-66-5
7-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-5-ethyl-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / pyridine / CH₂Cl₂ / 0.33 h / Ambient temperature

2: 1.) NaH, DMSO / 1.) 50 deg C, 2.) DMSO, 30 min

3: 76 percent / xylene / 4 h / 150 °C

4: 76 percent / NaH / xylene / 2 h / 150 °C

5: 98 percent / 48percent aq. HBr, AcOH / 0.08 h / Heating

6: 77 percent / diisopropylethylamine / CHCl₃

7: 69 percent / Pd(Ph₃P)4, LiCl / dioxane / 1.5 h / Heating

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; sodium hydride; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; lithium chloride; In 1,4-dioxane; dichloromethane; chloroform; xylene;
DOI:10.1021/jm00024a010