2-methoxy-N-(3-(6-(phenylamino)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)phenyl)benzamide

Base Information

Chemical Name:2-methoxy-N-(3-(6-(phenylamino)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)phenyl)benzamide
CAS No.:1428155-73-0
Molecular Formula:C₃₀H₂₈N₆O₃
Molecular Weight:520.591
Hs Code.:

Synonyms:2-methoxy-N-(3-(6-(phenylamino)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)phenyl)benzamide

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Chemical Property of 2-methoxy-N-(3-(6-(phenylamino)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)phenyl)benzamide

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Technology Process of 2-methoxy-N-(3-(6-(phenylamino)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)phenyl)benzamide

There total 5 articles about 2-methoxy-N-(3-(6-(phenylamino)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1428155-69-4
8-(3-aminophenyl)-N-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

: 579-75-9
2-Methoxybenzoic acid

: 1428155-73-0
2-methoxy-N-(3-(6-(phenylamino)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)phenyl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield:

: 7306-68-5
6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 1428155-73-0
2-methoxy-N-(3-(6-(phenylamino)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; palladium diacetate; XPhos / water; tert-butyl alcohol / 15 h / 110 °C / Inert atmosphere; Sealed tube

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 100 °C / Inert atmosphere; Sealed tube

4.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium diisopropyl amide; XPhos; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; tert-butyl alcohol; 1.1: |Buchwald-Hartwig Coupling / 3.1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield:

: 84602-83-5
N-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

: 1428155-73-0
2-methoxy-N-(3-(6-(phenylamino)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 100 °C / Inert atmosphere; Sealed tube

3.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; 2.1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2012.06.005