8-(3-aminophenyl)-N-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

Base Information

Chemical Name:8-(3-aminophenyl)-N-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine
CAS No.:1428155-69-4
Molecular Formula:C₂₂H₂₂N₆O
Molecular Weight:386.456
Hs Code.:

Synonyms:8-(3-aminophenyl)-N-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

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Chemical Property of 8-(3-aminophenyl)-N-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

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Technology Process of 8-(3-aminophenyl)-N-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

There total 4 articles about 8-(3-aminophenyl)-N-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1428155-65-0
8-iodo-N-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

: 30418-59-8,280563-63-5
3-Aminophenylboronic acid

: 1428155-69-4
8-(3-aminophenyl)-N-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 3h; Inert atmosphere; Sealed tube;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield:

: 7306-68-5
6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 1428155-69-4
8-(3-aminophenyl)-N-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; palladium diacetate; XPhos / water; tert-butyl alcohol / 15 h / 110 °C / Inert atmosphere; Sealed tube

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 100 °C / Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; potassium carbonate; lithium diisopropyl amide; XPhos; In tetrahydrofuran; 1,4-dioxane; hexane; water; tert-butyl alcohol; 1.1: |Buchwald-Hartwig Coupling / 3.1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield:

: 84602-83-5
N-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

: 1428155-69-4
8-(3-aminophenyl)-N-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 100 °C / Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; water; 2.1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2012.06.005