(4S)-N-((S)-1-phenethyl)-4-phenyl-3-chloroacetyl-3-azapentanamide

Base Information

• Chemical Name: (4S)-N-((S)-1-phenethyl)-4-phenyl-3-chloroacetyl-3-azapentanamide
• CAS No.: 158547-55-8
• Molecular Formula: C₂₀H₂₃ClN₂O₂
• Molecular Weight: 358.868
• Mol file: 158547-55-8.mol

Synonyms:(4S)-N-((S)-1-phenethyl)-4-phenyl-3-chloroacetyl-3-azapentanamide

Chemical Property of (4S)-N-((S)-1-phenethyl)-4-phenyl-3-chloroacetyl-3-azapentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S)-N-((S)-1-phenethyl)-4-phenyl-3-chloroacetyl-3-azapentanamide

There total 1 articles about (4S)-N-((S)-1-phenethyl)-4-phenyl-3-chloroacetyl-3-azapentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(4S)-N-((S)-1-phenyleth-1-yl)-4-phenyl-3-azapentanamide (143746-58-1) + chloroacetyl chloride (79-04-9) → (4S)-N-((S)-1-phenethyl)-4-phenyl-3-chloroacetyl-3-azapentanamide (158547-55-8)

Guidance literature:

With sodium carbonate; In water; acetone; at 0 ℃; for 2h;

DOI:10.1016/S0957-4166(00)86217-5

Reference yield: 93.0%

(4S)-N-((S)-1-phenethyl)-4-phenyl-3-chloroacetyl-3-azapentanamide (158547-55-8) → 1,4-N,N-[(S)-1-phenylethyl]-piperazine-2,5-dione (158547-56-9)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 2h;

DOI:10.1016/S0957-4166(00)86217-5

Reference yield:

(4S)-N-((S)-1-phenethyl)-4-phenyl-3-chloroacetyl-3-azapentanamide (158547-55-8) → (R)-1,4-Bis-((S)-1-phenyl-ethyl)-3-propyl-piperazine-2,5-dione (158547-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / 0 °C

2: 1.) LHMDS / 1.) THF, -10 deg C, 2 h, 2.) THF, -78 deg C, 3 h

With n-butyllithium; lithium hexamethyldisilazane; In tetrahydrofuran; hexane;

DOI:10.1016/S0957-4166(00)86217-5

upstream raw materials:

(4S)-N-((S)-1-phenyleth-1-yl)-4-phenyl-3-azapentanamide

chloroacetyl chloride

Downstream raw materials:

1,4-N,N-[(S)-1-phenylethyl]-piperazine-2,5-dione

(3R)-1,4-N,N-((S)-1-phenethyl)-3-(2-propenyl)piperazine-2,5-dione

(3S)-1,4-N,N-((S)-1-phenethyl)-3-(2-propenyl)piperazine-2,5-dione

(R)-1,4-Bis-((S)-1-phenyl-ethyl)-3-propyl-piperazine-2,5-dione