6,6a-dihydroisoindolo[2,1-α]quinazoline-5,11-dione

Base Information

Chemical Name:6,6a-dihydroisoindolo[2,1-α]quinazoline-5,11-dione
CAS No.:57097-71-9
Molecular Formula:C₁₅H₁₀N₂O₂
Molecular Weight:250.257
Hs Code.:
DSSTox Substance ID:DTXSID501229416
Nikkaji Number:J2.952.932I
ChEMBL ID:CHEMBL3407746

Synonyms:6,6a-dihydroisoindolo[2,1-α]quinazoline-5,11-dione

Suppliers and Price of 6,6a-dihydroisoindolo[2,1-α]quinazoline-5,11-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 6,6a-dihydroisoindolo[2,1-α]quinazoline-5,11-dione

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:250.074227566
Heavy Atom Count:19
Complexity:422

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C3NC(=O)C4=CC=CC=C4N3C2=O

Technology Process of 6,6a-dihydroisoindolo[2,1-α]quinazoline-5,11-dione

There total 6 articles about 6,6a-dihydroisoindolo[2,1-α]quinazoline-5,11-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 28144-70-9,88-68-6
anthranilic acid amide

: 119-67-5
o-carboxybenzaldehyde

: 57097-71-9
6,6a-dihydroisoindolo[2,1-α]quinazoline-5,11-dione

Guidance literature:: With toluene-4-sulfonic acid; In water; chlorobenzene; for 7h; Reflux;
DOI:10.1016/j.tetlet.2019.151315

Reference yield: 82.0%

: 201230-82-2
carbon monoxide

: 28144-70-9,88-68-6
anthranilic acid amide

: 6630-33-7
ortho-bromobenzaldehyde

: 57097-71-9
6,6a-dihydroisoindolo[2,1-α]quinazoline-5,11-dione

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; palladium dichloride; tri tert-butylphosphoniumtetrafluoroborate; In dimethyl sulfoxide; at 120 ℃; for 10h; under 760.051 Torr; Reagent/catalyst; Solvent; Temperature; regioselective reaction; Catalytic behavior; Schlenk technique;
DOI:10.1039/c7ob00256d

Reference yield:

: 136918-14-4,85-41-6
phthalimide

: 57097-71-9
5-Hydroxy-6aH-isoindolo[2,1-a]quinazolin-11-one

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / acetonitrile / Ambient temperature

2: aq. H₂SO₄ / electrolysis

3: aq. H₂SO₄

With triethylamine; In sulfuric acid; acetonitrile;