4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(dimethylamino)propyl)benzamide

Base Information

• Chemical Name: 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(dimethylamino)propyl)benzamide
• CAS No.: 1602747-75-0
• Molecular Formula: C₂₇H₂₈Cl₂N₄O
• Molecular Weight: 495.452

Synonyms:4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(dimethylamino)propyl)benzamide

Chemical Property of 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(dimethylamino)propyl)benzamide

Chemical Property:

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Technology Process of 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(dimethylamino)propyl)benzamide

There total 6 articles about 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(dimethylamino)propyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazole-1-yl)methyl)benzoic acid (1602748-79-7) + 1-amino-3-(dimethylamino)propane (109-55-7) → 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(dimethylamino)propyl)benzamide (1602747-75-0)

Guidance literature:

4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazole-1-yl)methyl)benzoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

1-amino-3-(dimethylamino)propane; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.ejmech.2016.11.017

Reference yield: 24.0%

→ 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(dimethylamino)propyl)benzamide (1602747-75-0)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃;

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

1,2-diamino-benzene (95-54-5) → 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(dimethylamino)propyl)benzamide (1602747-75-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: polyphosphoric acid / 4 h / Inert atmosphere; Heating

2.1: sodium hydride / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide / tetrahydrofuran; water; methanol / 3 h / 20 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 20 °C / Inert atmosphere

4.2: 16 h / 20 °C / Inert atmosphere

With oxalyl dichloride; sodium hydride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2016.11.017

upstream raw materials:

1,2-diamino-benzene

2-(2,6-dichlorophenyl)acetic acid

2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazole

methyl 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)benzoate

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