Amstat

Base Information

• Chemical Name: Amstat
• CAS No.: 1197-18-8
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.213
• Hs Code.: 29224999
• Mol file: 1197-18-8.mol

Synonyms:trans-4-Aminomethylcyclohexane-1-carboxylic acid;trans-4-(Aminomethyl)cyclohexanecarboxylic acid;trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid;Acido tranexamico [INN-Spanish];4-(aminomethyl)cyclohexane-1-carboxylic acid;Cyclohexanecarboxylic acid, 4- (aminomethyl)-, trans-;Frenolyse;Tamcha;Cyclohexanecarboxylic acid,4-(aminomethyl)-,trans-;Trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid;trans-1-Aminomethylcyclohexane-4-carboxylic acid;Tranex;trans-4-(Aminomethyl)cyclohexanecarboxylic acid; Tranexamic Acid;Tranesamic acid;CYCLO CAPRON;Transamin;Tranexan;Rikavarin-S;Rikavarin (TN);4-(Aminomethyl)cyclohexanecarboxylic acid;Hexatron;Trans-p-(Aminomethyl)cyclohexanecarboxylic acid;Amikapron;Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-;Ugurol;trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid;

Chemical Property of Amstat

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 300 °C
• Refractive Index: 1.497
• Boiling Point: 300.201 °C at 760 mmHg
• PKA: pKa 4.3 (Uncertain);10.6 (Uncertain)
• Flash Point: 135.357 °C
• PSA: 63.32000
• Density: 1.096 g/cm³
• LogP: 1.53640
• Storage Temp.: Store at 0°C
• Solubility.: Freely soluble in water and in glacial acetic acid, practically insoluble in acetone and in ethanol (96 per cent).
• Water Solubility.: 1g/6ml

Purity/Quality:

99% ^*data from raw suppliers

Tranexamic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Indications: Various bleedings caused by acute or chronic, localized or systemic primary hyperfibrinolysis; secondary hyperfibrinolytic state caused by disseminated intravascular coagulation. Generally do not use this product before heparinization. Trauma or surgical bleeding in tissue and organs with abundant plasminogen activators such as prostate, urethra, lung, brain, uterus, adrenal glands, and thyroid. An antagonist of tissue plasminogen activator (t-PA), streptokinase, and urokinase. Fibrinolytic hemorrhage caused by artificial abortion, early placental detachment, stillbirth and amniotic fluid embolism; and increased menorrhagia caused by pathological intrauterine fibrinolysis. Cerebral neuropathy mild bleeding, such as subarachnoid hemorrhage and intracranial aneurysm hemorrhage, the effect of Amstat in this condition is better than that of other anti-fibrinolytic agents. Special attention must be paid to the risk of cerebral edema or cerebral infarction. ?For severe patients with surgical indications, this product can only be used as an adjuvant drug. For the treatment of hereditary angioneurotic edema, it can reduce the number and severity of episodes. Used in patients with hemophilia for their active hemorrhage in combination with others drug. Hemophilia patients with factor VIII or factor IX deficiency in their tooth extraction or oral surgery in case of operating bleeding.
• Uses: Antifibrinolytic agent; blocks lysine binding sites of plasminogen. Hemostatic. Used as lysine analogue to characterize binding sites in plasminogen Fibrinolysis, the cleavage of fibrin by plasmin, is a normal step in the dissolution of fibrin clots after wound repair. Tranexamic acid is an inhibitor of fibrinolysis that blocks the interaction of plasmin with fibrin (IC50 = 3.1 μM). It is a lysine mimetic that binds the lysine binding site in plasmin. Antifibrinolytic agents have value when fibrinolytic activity is abnormally high or when coagulation is impaired.
• Therapeutic Function: Coagulant
• Clinical Use: Haemostatic agent
• Drug interactions: Potentially hazardous interactions with other drugs None known

Technology Process of Amstat

There total 8 articles about Amstat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92%

concentrated ammonia water + trans-4-cyanocyclohexane-1-ylcarboxylic acid (15177-68-1) → trans-4-aminomethyl-cyclohexyl-carboxylic acid (1197-18-8)

Guidance literature:

aluminum nickel; In methanol; water; acetone;

Reference yield: 92%

→ trans-4-aminomethyl-cyclohexyl-carboxylic acid (1197-18-8)

Guidance literature:

Reference yield: 85.11%

methyl 4-(acetamidomethyl)cyclohexane-1-carboxylate (51782-10-6) → trans-4-aminomethyl-cyclohexyl-carboxylic acid (1197-18-8)

Guidance literature:

With barium hydroxide octahydrate; hydrogen; In ethanol; water; at 250 ℃; for 7.5h; under 7500.75 - 30003 Torr; Pressure; Temperature;

upstream raw materials:

trans-4-cyanocyclohexane-1-ylcarboxylic acid

methyl trans-4-cyanocyclohexane-1-carboxylate

C₁₂H₁₇NO₅

4-cyanobenzoic acid methyl ester

Downstream raw materials:

4-(5-benzyl-6-thioxo-[1,3,5]thiadiazinan-3-ylmethyl)-cyclohexanecarboxylic acid

4-aminomethyl-cyclohexanecarboxylic acid methyl ester

methyl 3-propionate hydrochloride

4-((2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-7-sulfonamido)methyl)cyclohexanecarboxylic acid

Refernces

• 1、 -. "Method for synthesizing formic acid". . . Retrieved 2022/04/03.
• 2、 -. "A 4-acetamidomethyl methyl cyclohexyl method for producing methyl formate". . . Retrieved 2017/02/28.