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Base Information Edit
  • Chemical Name:Amstat
  • CAS No.:1197-18-8
  • Molecular Formula:C8H15NO2
  • Molecular Weight:157.213
  • Hs Code.:29224999
  • Mol file:1197-18-8.mol

Synonyms:trans-4-Aminomethylcyclohexane-1-carboxylic acid;trans-4-(Aminomethyl)cyclohexanecarboxylic acid;trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid;Acido tranexamico [INN-Spanish];4-(aminomethyl)cyclohexane-1-carboxylic acid;Cyclohexanecarboxylic acid, 4- (aminomethyl)-, trans-;Frenolyse;Tamcha;Cyclohexanecarboxylic acid,4-(aminomethyl)-,trans-;Trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid;trans-1-Aminomethylcyclohexane-4-carboxylic acid;Tranex;trans-4-(Aminomethyl)cyclohexanecarboxylic acid; Tranexamic Acid;Tranesamic acid;CYCLO CAPRON;Transamin;Tranexan;Rikavarin-S;Rikavarin (TN);4-(Aminomethyl)cyclohexanecarboxylic acid;Hexatron;Trans-p-(Aminomethyl)cyclohexanecarboxylic acid;Amikapron;Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-;Ugurol;trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid;

Chemical Property of Amstat Edit
Chemical Property:
  • Appearance/Colour:white crystalline powder 
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:300 °C 
  • Refractive Index:1.497 
  • Boiling Point:300.201 °C at 760 mmHg 
  • PKA:pKa 4.3 (Uncertain);10.6 (Uncertain) 
  • Flash Point:135.357 °C 
  • PSA:63.32000 
  • Density:1.096 g/cm3 
  • LogP:1.53640 
  • Storage Temp.:Store at 0°C 
  • Solubility.:Freely soluble in water and in glacial acetic acid, practically insoluble in acetone and in ethanol (96 per cent). 
  • Water Solubility.:1g/6ml 

99% *data from raw suppliers

Tranexamic acid *data from reagent suppliers

Safty Information:
  • Pictogram(s): IrritantXi 
  • Hazard Codes:Xi 
  • Statements: 36/37/38 
  • Safety Statements: 26-36-37/39 
MSDS Files:

SDS file from LookChem

  • Indications Various bleedings caused by acute or chronic, localized or systemic primary hyperfibrinolysis; secondary hyperfibrinolytic state caused by disseminated intravascular coagulation. Generally do not use this product before heparinization. Trauma or surgical bleeding in tissue and organs with abundant plasminogen activators such as prostate, urethra, lung, brain, uterus, adrenal glands, and thyroid. An antagonist of tissue plasminogen activator (t-PA), streptokinase, and urokinase. Fibrinolytic hemorrhage caused by artificial abortion, early placental detachment, stillbirth and amniotic fluid embolism; and increased menorrhagia caused by pathological intrauterine fibrinolysis. Cerebral neuropathy mild bleeding, such as subarachnoid hemorrhage and intracranial aneurysm hemorrhage, the effect of Amstat in this condition is better than that of other anti-fibrinolytic agents. Special attention must be paid to the risk of cerebral edema or cerebral infarction. ?For severe patients with surgical indications, this product can only be used as an adjuvant drug. For the treatment of hereditary angioneurotic edema, it can reduce the number and severity of episodes. Used in patients with hemophilia for their active hemorrhage in combination with others drug. Hemophilia patients with factor VIII or factor IX deficiency in their tooth extraction or oral surgery in case of operating bleeding.
  • Uses Antifibrinolytic agent; blocks lysine binding sites of plasminogen. Hemostatic. Used as lysine analogue to characterize binding sites in plasminogen Fibrinolysis, the cleavage of fibrin by plasmin, is a normal step in the dissolution of fibrin clots after wound repair. Tranexamic acid is an inhibitor of fibrinolysis that blocks the interaction of plasmin with fibrin (IC50 = 3.1 μM). It is a lysine mimetic that binds the lysine binding site in plasmin. Antifibrinolytic agents have value when fibrinolytic activity is abnormally high or when coagulation is impaired.
  • Therapeutic Function Coagulant
  • Clinical Use Haemostatic agent
  • Drug interactions Potentially hazardous interactions with other drugs None known
Marketing and Price of Amstat
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Tranexamic acid
  • 250g
  • $ 565
  • TRC
  • Tranexamic acid
  • 1g
  • $ 55
  • TCI Chemical
  • trans-4-(Aminomethyl)cyclohexanecarboxylic Acid >98.0%(GC)(T)
  • 25g
  • $ 32
  • TCI Chemical
  • trans-4-(Aminomethyl)cyclohexanecarboxylic Acid >98.0%(GC)(T)
  • 5g
  • $ 14
  • TCI Chemical
  • trans-4-(Aminomethyl)cyclohexanecarboxylic Acid >98.0%(GC)(T)
  • 100g
  • $ 92
  • SynQuest Laboratories
  • trans-4-(Aminomethyl)cyclohexanecarboxylic acid 98.0%
  • 100 g
  • $ 92
  • SynQuest Laboratories
  • trans-4-(Aminomethyl)cyclohexanecarboxylic acid 98.0%
  • 1 kg
  • $ 672
  • SynQuest Laboratories
  • trans-4-(Aminomethyl)cyclohexanecarboxylic acid 98.0%
  • 500 g
  • $ 356
  • Sigma-Aldrich
  • trans-4-(Aminomethyl)cyclohexanecarboxylic acid 97%
  • 250g
  • $ 516
  • Sigma-Aldrich
  • Tranexamic acid United States Pharmacopeia (USP) Reference Standard
  • 200mg
  • $ 366
Total 280 raw suppliers
Technology Process of Amstat

There total 8 articles about Amstat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Guidance literature:
With barium hydroxide octahydrate; hydrogen; In ethanol; water; at 250 ℃; for 7.5h; under 7500.75 - 30003 Torr; Pressure; Temperature;
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