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| CAS No.: | 1197-18-8 |
|---|---|
| Name: | Amstat |
| Article Data: | 33 |
| Cas Database | |
| Molecular Structure: | |
|
|
|
| Formula: | C8H15NO2 |
| Molecular Weight: | 157.213 |
| Synonyms: | trans-4-Aminomethylcyclohexane-1-carboxylic acid;trans-4-(Aminomethyl)cyclohexanecarboxylic acid;trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid;Acido tranexamico [INN-Spanish];4-(aminomethyl)cyclohexane-1-carboxylic acid;Cyclohexanecarboxylic acid, 4- (aminomethyl)-, trans-;Frenolyse;Tamcha;Cyclohexanecarboxylic acid,4-(aminomethyl)-,trans-;Trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid;trans-1-Aminomethylcyclohexane-4-carboxylic acid;Tranex;trans-4-(Aminomethyl)cyclohexanecarboxylic acid; Tranexamic Acid;Tranesamic acid;CYCLO CAPRON;Transamin;Tranexan;Rikavarin-S;Rikavarin (TN);4-(Aminomethyl)cyclohexanecarboxylic acid;Hexatron;Trans-p-(Aminomethyl)cyclohexanecarboxylic acid;Amikapron;Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-;Ugurol;trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid; |
| EINECS: | 214-818-2 |
| Density: | 1.096 g/cm3 |
| Melting Point: | 300 °C |
| Boiling Point: | 300.201 °C at 760 mmHg |
| Flash Point: | 135.357 °C |
| Solubility: | water: 1 g/6mL |
| Appearance: | white crystalline powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36-37/39 |
| PSA: | 63.32000 |
| LogP: | 1.53640 |
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- 15177-68-1
trans-4-cyanocyclohexane-1-ylcarboxylic acid
- 1197-18-8
trans-4-aminomethyl-cyclohexyl-carboxylic acid
| Conditions | Yield |
|---|---|
| aluminum nickel In methanol; water; acetone | 92% |
- 51782-10-6
methyl 4-(acetamidomethyl)cyclohexane-1-carboxylate
- 1197-18-8
trans-4-aminomethyl-cyclohexyl-carboxylic acid
| Conditions | Yield |
|---|---|
| With barium hydroxide octahydrate; hydrogen In ethanol; water at 250℃; under 7500.75 - 30003 Torr; for 7.5h; Pressure; Temperature; | 85.11% |
- 19145-95-0
methyl trans-4-cyanocyclohexane-1-carboxylate
- 1197-18-8
trans-4-aminomethyl-cyclohexyl-carboxylic acid
| Conditions | Yield |
|---|---|
| With triethylamine In hydrous methanol |
- 953817-12-4
C12H17NO5
A
- 108-31-6
maleic anhydride
B
- 1197-18-8
trans-4-aminomethyl-cyclohexyl-carboxylic acid
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water for 1h; Kinetics; |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: sodium acetate; hydrogen; ruthenium-carbon composite / 7 h / 40 °C / 6750.68 - 7500.75 Torr 2: hydrogen; potassium acetate / toluene / 13 h / 150 °C / 7500.75 - 75007.5 Torr 3: hydrogen; barium hydroxide octahydrate / ethanol; water / 7.5 h / 250 °C / 7500.75 - 30003 Torr View Scheme |
- 24424-99-5
di-tert-butyl dicarbonate
- 1197-18-8
trans-4-aminomethyl-cyclohexyl-carboxylic acid
| Conditions | Yield |
|---|---|
| With hydrogenchloride In 1,4-dioxane; sodium hydroxide | 100% |
- 24424-99-5
di-tert-butyl dicarbonate
- 1197-18-8
trans-4-aminomethyl-cyclohexyl-carboxylic acid
- 27687-14-5
trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid
| Conditions | Yield |
|---|---|
| With sodium hydrogencarbonate In water at 20℃; for 18h; Industrial scale; | 97% |
| With sodium hydrogencarbonate In 1,4-dioxane | 95% |
| With sodium hydroxide In water; tert-butyl alcohol for 18h; Ambient temperature; | 94% |
- 1197-18-8
trans-4-aminomethyl-cyclohexyl-carboxylic acid
- 501-53-1
benzyl chloroformate
- 27687-12-3
(1r,4r)-4-({[(benzyloxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid
| Conditions | Yield |
|---|---|
| With sodium hydroxide In tetrahydrofuran; water at 20℃; for 2h; | 97% |
| With sodium hydroxide | |
| With sodium hydroxide for 1h; |
- 1197-18-8
trans-4-aminomethyl-cyclohexyl-carboxylic acid
- 2937-50-0
Allyl chloroformate
- 177583-51-6
trans-4-allyloxycarbonylaminomethylcyclohexanecarboxylic acid
| Conditions | Yield |
|---|---|
| With sodium hydroxide In 1,4-dioxane | 97% |
- 64-17-5
ethanol
- 1197-18-8
trans-4-aminomethyl-cyclohexyl-carboxylic acid
- 19878-18-3
ethyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride
| Conditions | Yield |
|---|---|
| With thionyl chloride at 0 - 70℃; for 1.16667h; | 96% |
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Chemistry
Product Name: Tranexamic acid (CAS NO.1197-18-8)
Molecular Formula: C8H15NO2
Molecular Weight: 157.21g/mol
EINECS: 214-818-2
Melting point: 300 °C
Water solubility: 1g/6ml
Storage temp.: Store at 0 °C
Index of Refraction: 1.497
Molar Refractivity: 42.007 cm3
Molar Volume: 143.445 cm3
Surface Tension: 43.639 dyne/cm
Density: 1.096 g/cm3
Flash Point: 135.357 °C
Enthalpy of Vaporization: 59.426 kJ/mol
Boiling Point: 300.201 °C at 760 mmHg
XLogP3-AA: -2
H-Bond Donor: 2
H-Bond Acceptor: 2
Structure Descriptors of Tranexamic acid (CAS NO.1197-18-8):
IUPAC Name: 4-(aminomethyl)cyclohexane-1-carboxylic acid
Canonical SMILES: C1CC(CCC1CN)C(=O)O
InChI: InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)
InChIKey: GYDJEQRTZSCIOI-UHFFFAOYSA-N
Product Categories: 4-Substituted Cyclohexanecarboxylic Acids; API's
Toxicity Data With Reference
| 1. | orl-mus TDLo:9 mg/kg (female 7-12D post):REP | OYYAA2 Oyo Yakuri. Pharmacometrics. 5 (1971),415. | ||
| 2. | orl-rat TDLo:9 mg/kg (female 9-14D post):TER | OYYAA2 Oyo Yakuri. Pharmacometrics. 5 (1971),415. | ||
| 3. | orl-rat LD50:3000 mg/kg | APTOA6 Acta Pharmacologica et Toxicologica. 22 (1965),340. | ||
| 4. | ipr-rat LD50:4200 mg/kg | MEIEDD Merck Index. 10 (1983),1269. | ||
| 5. | scu-rat LD50:4620 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),512. | ||
| 6. | ivn-rat LD50:1200 mg/kg | APTOA6 Acta Pharmacologica et Toxicologica. 22 (1965),340. | ||
| 7. | scu-mus LD50:5310 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),512. | ||
| 8. | ivn-mus LD50:1350 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),512. | ||
| 9. | ivn-dog LD50:1110 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),512. |
Safety Profile
Moderately toxic by ingestion and intravenous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes such as NOx. A hemostatic agent.
The Hazard Codes of Tranexamic acid (CAS NO.1197-18-8) Xi:
;
The Risk Statements R36/37/38 : Irritating to eyes, respiratory system and skin.
The Safety Statements S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.S37/39 : Wear suitable gloves and eye/face protection.
Specification
Tranexamic acid , its CAS NO. is 1197-18-8, the synonyms are trans-4-Aminomethylcyclohexane-1-carboxylate ; trans-4-(Aminomethyl)cyclohexanecarboxylic acid ; Amstat .
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