2-((methoxymethoxy)methyl)-4-fluorophenylboronic acid

Base Information

• Chemical Name: 2-((methoxymethoxy)methyl)-4-fluorophenylboronic acid
• CAS No.: 943310-56-3
• Molecular Formula: C₉H₁₂BFO₄
• Molecular Weight: 214.001
• Mol file: 943310-56-3.mol

Synonyms:2-((methoxymethoxy)methyl)-4-fluorophenylboronic acid

Chemical Property of 2-((methoxymethoxy)methyl)-4-fluorophenylboronic acid

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((methoxymethoxy)methyl)-4-fluorophenylboronic acid

There total 4 articles about 2-((methoxymethoxy)methyl)-4-fluorophenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-5-fluorobenzyl alcohol (202865-66-5) → 2-((methoxymethoxy)methyl)-4-fluorophenylboronic acid (943310-56-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: i-Pr₂NEt / tetrahydrofuran / 20 °C

2.1: sec-BuLi; (MeO)3B / tetrahydrofuran / -78 - 20 °C

2.2: aq. NaOH / tetrahydrofuran

With Trimethyl borate; sec.-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1021/jm0603724

Reference yield:

2-bromo-5-fluoro-[1-(methoxymethoxy)methyl]benzene (845301-93-1) + Triisopropyl borate (5419-55-6) → 2-((methoxymethoxy)methyl)-4-fluorophenylboronic acid (943310-56-3)

Guidance literature:

2-bromo-5-fluoro-[1-(methoxymethoxy)methyl]benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.833333h;

Triisopropyl borate; In tetrahydrofuran; hexane; at -78 ℃; for 1.66667h;

Reference yield:

2-bromo-5-fluoro-[1-(methoxymethoxy)methyl]benzene (845301-93-1) → 2-((methoxymethoxy)methyl)-4-fluorophenylboronic acid (943310-56-3)

Guidance literature:

2-bromo-5-fluoro-[1-(methoxymethoxy)methyl]benzene; With Trimethyl borate; sec.-butyllithium; In tetrahydrofuran; at -78 - 20 ℃;

With sodium hydroxide; In tetrahydrofuran;

DOI:10.1021/jm0603724

upstream raw materials:

2-bromo-5-fluoro-[1-(methoxymethoxy)methyl]benzene

2-bromo-5-fluorobenzaldehyde

2-bromo-5-fluorobenzyl alcohol

Triisopropyl borate

Downstream raw materials:

tavaborole