Ethyl 2-(7-((S)-3-(4-chlorophenylsulfonamido)piperidin-1-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)pentanoate

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Chemical Name:Ethyl 2-(7-((S)-3-(4-chlorophenylsulfonamido)piperidin-1-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)pentanoate
CAS No.:1313376-63-4
Molecular Formula:C₂₅H₃₂ClN₅O₄S
Molecular Weight:534.079
Hs Code.:

Synonyms:Ethyl 2-(7-((S)-3-(4-chlorophenylsulfonamido)piperidin-1-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)pentanoate

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Chemical Property of Ethyl 2-(7-((S)-3-(4-chlorophenylsulfonamido)piperidin-1-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)pentanoate

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Technology Process of Ethyl 2-(7-((S)-3-(4-chlorophenylsulfonamido)piperidin-1-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)pentanoate

There total 3 articles about Ethyl 2-(7-((S)-3-(4-chlorophenylsulfonamido)piperidin-1-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1313378-30-1
ethyl 2-(7-((S)-3-(tert-butoxycarbonylamino)piperidin-1-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)pentanoate

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 1313376-63-4
Ethyl 2-(7-((S)-3-(4-chlorophenylsulfonamido)piperidin-1-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)pentanoate

Guidance literature:: ethyl 2-(7-((S)-3-(tert-butoxycarbonylamino)piperidin-1-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)pentanoate; With trifluoroacetic acid; In dichloromethane; for 0.5h;

4-chlorobenzenesulfonyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 216854-23-8,172603-05-3
tert-butyl (S)-piperidin-3-yl-carbamate

: 1313376-63-4
Ethyl 2-(7-((S)-3-(4-chlorophenylsulfonamido)piperidin-1-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / toluene / 3 h / 90 °C / Sealed tube

2.1: trifluoroacetic acid / dichloromethane / 0.5 h

2.2: 1 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; toluene;

Reference yield:

: 1313378-06-1
ethyl 2-(7-chloro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)pentanoate

: 1313376-63-4
Ethyl 2-(7-((S)-3-(4-chlorophenylsulfonamido)piperidin-1-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / toluene / 3 h / 90 °C / Sealed tube

2.1: trifluoroacetic acid / dichloromethane / 0.5 h

2.2: 1 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; toluene;