N-(5-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl)acrylamide

Base Information

Chemical Name:N-(5-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl)acrylamide
CAS No.:1421373-52-5
Molecular Formula:C₂₇H₂₉N₇O₂
Molecular Weight:483.573
Hs Code.:

Synonyms:N-(5-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl)acrylamide

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Chemical Property of N-(5-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl)acrylamide

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Technology Process of N-(5-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl)acrylamide

There total 7 articles about N-(5-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1421372-32-8
N'-[4-(1H-indol-3-yl)pyrimidin-2-yl]-4-methoxy-6-(4-methylpiperazin-1-yl)benzene-1,3-diamine

: 814-68-6,25189-84-8
acryloyl chloride

: 1421373-52-5
N-(5-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1021/jm400822z

Reference yield:

: 1421372-33-9
4-(1H-indol-3-yl)-N-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl]pyrimidin-2-amine

: 1421373-52-5
N-(5-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: iron; ammonium chloride / water; ethanol / 18 h / 105 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.75 h / 2 - 20 °C / Cooling with ice

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water;

Reference yield:

: 1075705-01-9
4-fluoro-2-methoxy-5-nitro-phenylamine

: 1421373-52-5
N-(5-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / 18 h / 120 °C

2: 2,2,2-trifluoroethanol / 1 h / 120 °C / Microwave irradiation; Sealed tube

3: iron; ammonium chloride / water; ethanol / 18 h / 105 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.75 h / 2 - 20 °C / Cooling with ice

With iron; ammonium chloride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; 2,2,2-trifluoroethanol; water;