13-acetyl-6-oxo-8-phenyl-1,5,9,13-tetraazcycloheptadecane-1-carboxylic acid 2,2,2-trichloroethyl ester

Base Information

Chemical Name:13-acetyl-6-oxo-8-phenyl-1,5,9,13-tetraazcycloheptadecane-1-carboxylic acid 2,2,2-trichloroethyl ester
CAS No.:87510-19-8
Molecular Formula:C₂₄H₃₅Cl₃N₄O₄
Molecular Weight:549.925
Hs Code.:

Synonyms:13-acetyl-6-oxo-8-phenyl-1,5,9,13-tetraazcycloheptadecane-1-carboxylic acid 2,2,2-trichloroethyl ester

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Chemical Property of 13-acetyl-6-oxo-8-phenyl-1,5,9,13-tetraazcycloheptadecane-1-carboxylic acid 2,2,2-trichloroethyl ester

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Technology Process of 13-acetyl-6-oxo-8-phenyl-1,5,9,13-tetraazcycloheptadecane-1-carboxylic acid 2,2,2-trichloroethyl ester

There total 14 articles about 13-acetyl-6-oxo-8-phenyl-1,5,9,13-tetraazcycloheptadecane-1-carboxylic acid 2,2,2-trichloroethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 87499-89-6
13-acetyl-4-oxo-2-phenyl-3,4,6,7,9,10,11,12,14,15-dodecahydro-5H-1,4a,8,13-tetraazabenzocyclotridecene-8-carboxylic acid 2,2,2-trichloroethyl ester

: 87510-19-8
13-acetyl-6-oxo-8-phenyl-1,5,9,13-tetraazcycloheptadecane-1-carboxylic acid 2,2,2-trichloroethyl ester

Guidance literature:: With sodium cyanoborohydride; In acetic acid; 1.) 25 deg C, 2 h and 50 deg C, 1 h 2.) 25 deg C, 12 h;
DOI:10.1016/S0040-4039(00)88197-6

Reference yield:

: 5661-55-2
4-phenylazetidin-2-one

: 87510-19-8
13-acetyl-6-oxo-8-phenyl-1,5,9,13-tetraazcycloheptadecane-1-carboxylic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 59 percent / benzene / 15 h / Heating

2.1: HCl gas / CH₂Cl₂ / 1 h / 0 °C

2.2: 80 percent / DMAP / CH₂Cl₂ / 1 h / 20 °C

3.1: 88 percent / NaBH₃CN / acetic acid / 20 - 50 °C

With hydrogenchloride; sodium cyanoborohydride; In dichloromethane; acetic acid; benzene; 1.1: Bormann condensation;
DOI:10.1016/S0040-4020(02)00731-7

Reference yield:

: 84927-09-3
4-oxo-1,5,9-triazacyclotridecan-1,9-dicarboxylic acid 1-tert-butyl ester 9-(2,2,2-trichloroethyl)ester

: 87510-19-8
13-acetyl-6-oxo-8-phenyl-1,5,9,13-tetraazcycloheptadecane-1-carboxylic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4 Angstroem molecular sieves / CH₂Cl₂ / 1.5 h / 20 °C

2.1: 59 percent / benzene / 15 h / Heating

3.1: HCl gas / CH₂Cl₂ / 1 h / 0 °C

3.2: 80 percent / DMAP / CH₂Cl₂ / 1 h / 20 °C

4.1: 88 percent / NaBH₃CN / acetic acid / 20 - 50 °C

With hydrogenchloride; 4 A molecular sieve; sodium cyanoborohydride; In dichloromethane; acetic acid; benzene; 2.1: Bormann condensation;
DOI:10.1016/S0040-4020(02)00731-7