13-acetyl-4-oxo-2-phenyl-3,4,6,7,9,10,11,12,14,15-dodecahydro-5H-1,4a,8,13-tetraazabenzocyclotridecene-8-carboxylic acid 2,2,2-trichloroethyl ester

Base Information

Chemical Name:13-acetyl-4-oxo-2-phenyl-3,4,6,7,9,10,11,12,14,15-dodecahydro-5H-1,4a,8,13-tetraazabenzocyclotridecene-8-carboxylic acid 2,2,2-trichloroethyl ester
CAS No.:87499-89-6
Molecular Formula:C₂₄H₃₁Cl₃N₄O₄
Molecular Weight:545.894
Hs Code.:

13-acetyl-4-oxo-2-phenyl-3,4,6,7,9,10,11,12,14,15-dodecahydro-5H-1,4a,8,13-tetraazabenzocyclotridecene-8-carboxylic acid 2,2,2-trichloroethyl ester

Synonyms:13-acetyl-4-oxo-2-phenyl-3,4,6,7,9,10,11,12,14,15-dodecahydro-5H-1,4a,8,13-tetraazabenzocyclotridecene-8-carboxylic acid 2,2,2-trichloroethyl ester

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Chemical Property of 13-acetyl-4-oxo-2-phenyl-3,4,6,7,9,10,11,12,14,15-dodecahydro-5H-1,4a,8,13-tetraazabenzocyclotridecene-8-carboxylic acid 2,2,2-trichloroethyl ester

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Technology Process of 13-acetyl-4-oxo-2-phenyl-3,4,6,7,9,10,11,12,14,15-dodecahydro-5H-1,4a,8,13-tetraazabenzocyclotridecene-8-carboxylic acid 2,2,2-trichloroethyl ester

There total 15 articles about 13-acetyl-4-oxo-2-phenyl-3,4,6,7,9,10,11,12,14,15-dodecahydro-5H-1,4a,8,13-tetraazabenzocyclotridecene-8-carboxylic acid 2,2,2-trichloroethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4-Oxo-2-phenyl-2,3,4,6,7,9,10,11,12,13,14,15-dodecahydro-5H-1,4a,8,13-tetraaza-benzocyclotridecene-8-carboxylic acid 2,2,2-trichloro-ethyl ester

: 75-36-5
acetyl chloride

: 87499-89-6
13-acetyl-4-oxo-2-phenyl-3,4,6,7,9,10,11,12,14,15-dodecahydro-5H-1,4a,8,13-tetraazabenzocyclotridecene-8-carboxylic acid 2,2,2-trichloroethyl ester

Guidance literature:: With dmap; In dichloromethane; at 25 ℃;
DOI:10.1016/S0040-4039(00)88197-6

Reference yield: 80.0%

: 87499-88-5
4-oxo-2-phenyl-3,4,6,7,9,10,11,12,14,15-decahydro-2H,5H-1,4a,8,13-tetraazabenzocyclotridecene-8,13-dicarboxylic acid 13-tert-butyl ester 8-(2,2,2-trichloroethyl) ester

: 75-36-5
acetyl chloride

: 87499-89-6
13-acetyl-4-oxo-2-phenyl-3,4,6,7,9,10,11,12,14,15-dodecahydro-5H-1,4a,8,13-tetraazabenzocyclotridecene-8-carboxylic acid 2,2,2-trichloroethyl ester

Guidance literature:: 4-oxo-2-phenyl-3,4,6,7,9,10,11,12,14,15-decahydro-2H,5H-1,4a,8,13-tetraazabenzocyclotridecene-8,13-dicarboxylic acid 13-tert-butyl ester 8-(2,2,2-trichloroethyl) ester; With hydrogenchloride; In dichloromethane; at 0 ℃; for 1h;

acetyl chloride; With dmap; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/S0040-4020(02)00731-7

Reference yield:

: 5661-55-2
4-phenylazetidin-2-one

: 87499-89-6
13-acetyl-4-oxo-2-phenyl-3,4,6,7,9,10,11,12,14,15-dodecahydro-5H-1,4a,8,13-tetraazabenzocyclotridecene-8-carboxylic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 59 percent / benzene / 15 h / Heating

2.1: HCl gas / CH₂Cl₂ / 1 h / 0 °C

2.2: 80 percent / DMAP / CH₂Cl₂ / 1 h / 20 °C

With hydrogenchloride; In dichloromethane; benzene; 1.1: Bormann condensation;
DOI:10.1016/S0040-4020(02)00731-7