4-(3-(benzyloxy)phenyl)-2-(ethylthio)-6-(trifluoromethyl)pyrimidine

Base Information

• Chemical Name: 4-(3-(benzyloxy)phenyl)-2-(ethylthio)-6-(trifluoromethyl)pyrimidine
• CAS No.: 1443033-42-8
• Molecular Formula: C₂₀H₁₇F₃N₂OS
• Molecular Weight: 390.429
• Mol file: 1443033-42-8.mol

Synonyms:4-(3-(benzyloxy)phenyl)-2-(ethylthio)-6-(trifluoromethyl)pyrimidine

Chemical Property of 4-(3-(benzyloxy)phenyl)-2-(ethylthio)-6-(trifluoromethyl)pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-(3-(benzyloxy)phenyl)-2-(ethylthio)-6-(trifluoromethyl)pyrimidine

There total 3 articles about 4-(3-(benzyloxy)phenyl)-2-(ethylthio)-6-(trifluoromethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

4-(3-(benzyloxy)phenyl)-2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidine + sodium thioethylate (811-51-8) → 4-(3-(benzyloxy)phenyl)-2-(ethylthio)-6-(trifluoromethyl)pyrimidine (1443033-42-8)

Guidance literature:

With ethanethiol; In tetrahydrofuran; at 100 ℃; for 0.333333h; Microwave irradiation; Sealed tube;

DOI:10.1124/dmd.113.052183

Reference yield:

4-Chloro-2-methylthio-6-(trifluoromethyl)pyrimidine (16097-63-5) → 4-(3-(benzyloxy)phenyl)-2-(ethylthio)-6-(trifluoromethyl)pyrimidine (1443033-42-8)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane / 18 h / 85 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C

3: ethanethiol / tetrahydrofuran / 0.33 h / 100 °C / Microwave irradiation; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; ethanethiol; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 1: |Suzuki Coupling;

DOI:10.1124/dmd.113.052183

Reference yield:

3-(benzyloxy)phenylboronic acid (156682-54-1) → 4-(3-(benzyloxy)phenyl)-2-(ethylthio)-6-(trifluoromethyl)pyrimidine (1443033-42-8)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane / 18 h / 85 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C

3: ethanethiol / tetrahydrofuran / 0.33 h / 100 °C / Microwave irradiation; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; ethanethiol; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 1: |Suzuki Coupling;

DOI:10.1124/dmd.113.052183

upstream raw materials:

4-Chloro-2-methylthio-6-(trifluoromethyl)pyrimidine

3-(benzyloxy)phenylboronic acid

sodium thioethylate

Downstream raw materials:

BETP