tert-butyl 2-(1-(1-(4-chlorophenyl)cyclobutyl)-3,4-dihydroisoquinolin-7-yloxy)ethylcarbamate

Base Information

Chemical Name:tert-butyl 2-(1-(1-(4-chlorophenyl)cyclobutyl)-3,4-dihydroisoquinolin-7-yloxy)ethylcarbamate
CAS No.:1190643-33-4
Molecular Formula:C₂₆H₃₁ClN₂O₃
Molecular Weight:454.997
Hs Code.:

Synonyms:tert-butyl 2-(1-(1-(4-chlorophenyl)cyclobutyl)-3,4-dihydroisoquinolin-7-yloxy)ethylcarbamate

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Chemical Property of tert-butyl 2-(1-(1-(4-chlorophenyl)cyclobutyl)-3,4-dihydroisoquinolin-7-yloxy)ethylcarbamate

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Technology Process of tert-butyl 2-(1-(1-(4-chlorophenyl)cyclobutyl)-3,4-dihydroisoquinolin-7-yloxy)ethylcarbamate

There total 5 articles about tert-butyl 2-(1-(1-(4-chlorophenyl)cyclobutyl)-3,4-dihydroisoquinolin-7-yloxy)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1190644-17-7
1-[1-(4-chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-ol

: 39684-80-5
2-(tert-butoxycarbonylamino)ethyl bromide

: 1190643-33-4
tert-butyl 2-(1-(1-(4-chlorophenyl)cyclobutyl)-3,4-dihydroisoquinolin-7-yloxy)ethylcarbamate

Guidance literature:: 1-[1-(4-chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-ol; With sodium hydride; In N,N-dimethyl acetamide; at 20 ℃;

2-(tert-butoxycarbonylamino)ethyl bromide; In N,N-dimethyl acetamide;

Reference yield:

: 916923-23-4
1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]cyclobutanecarboxamide

: 1190643-33-4
tert-butyl 2-(1-(1-(4-chlorophenyl)cyclobutyl)-3,4-dihydroisoquinolin-7-yloxy)ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / toluene / 8 h / Reflux

2.1: water; hydrogen bromide / 4 h / 120 °C

2.2: pH 10

3.1: sodium hydride / N,N-dimethyl acetamide / 20 °C

With water; hydrogen bromide; sodium hydride; trichlorophosphate; In N,N-dimethyl acetamide; toluene;

Reference yield:

: 50921-39-6
1-(4-chlorophenyl)cyclobutane-1-carboxylic acid

: 1190643-33-4
tert-butyl 2-(1-(1-(4-chlorophenyl)cyclobutyl)-3,4-dihydroisoquinolin-7-yloxy)ethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 - 20 °C

2.1: trichlorophosphate / toluene / 8 h / Reflux

3.1: water; hydrogen bromide / 4 h / 120 °C

3.2: pH 10

4.1: sodium hydride / N,N-dimethyl acetamide / 20 °C

With dmap; water; hydrogen bromide; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In dichloromethane; N,N-dimethyl acetamide; toluene;