(3aR,5R,6S,6aR)-6-(2-bromo-5-methoxybenzyloxy)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxole

Base Information

Chemical Name:(3aR,5R,6S,6aR)-6-(2-bromo-5-methoxybenzyloxy)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxole
CAS No.:200346-53-8
Molecular Formula:C₂₀H₂₇BrO₇
Molecular Weight:459.334
Hs Code.:

Synonyms:(3aR,5R,6S,6aR)-6-(2-bromo-5-methoxybenzyloxy)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aR,5R,6S,6aR)-6-(2-bromo-5-methoxybenzyloxy)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxole

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Technology Process of (3aR,5R,6S,6aR)-6-(2-bromo-5-methoxybenzyloxy)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxole

There total 1 articles about (3aR,5R,6S,6aR)-6-(2-bromo-5-methoxybenzyloxy)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 19614-12-1
2-bromo-5-methoxybenzyl bromide

: 582-52-5
1,2:5,6-di-O-isopropylidene-α-D-glucofuranose

: 200346-53-8
(3aR,5R,6S,6aR)-6-(2-bromo-5-methoxybenzyloxy)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxole

Guidance literature:: With sodium hydroxide; tetrabutylammomium bromide; In dichloromethane; at 25 ℃; for 12h;

Reference yield:

: 200346-53-8
(3aR,5R,6S,6aR)-6-(2-bromo-5-methoxybenzyloxy)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxole

: 200346-55-0
(R)-1-[(3aR,5R,6S,6aR)-6-(2-Bromo-5-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethane-1,2-diol

Guidance literature:: With acetic acid; at 25 ℃; for 12h; Yield given;
DOI:10.1039/a706249d

Reference yield:

: 200346-53-8
(3aR,5R,6S,6aR)-6-(2-bromo-5-methoxybenzyloxy)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxole

: 866890-78-0
(3aR,6R,6aR)-6-(2-bromo-5-methoxy-benzyloxy)-2,2-dimethyl-5-methylene-tetrahydro-furo[2,3-d][1,3]dioxole

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / H₂O / 12 h / 20 °C

2: NaIO₄ / methanol; H₂O / 0 °C

3: NaBH₄ / ethanol / 2 h / 0 - 20 °C

4: imidazole; PPh₃; I₂ / benzene / 4 h / 0 - 20 °C

5: 70 percent / t-BuOK / tetrahydrofuran / 1.5 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; potassium tert-butylate; iodine; acetic acid; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; water; benzene;
DOI:10.1016/j.tet.2005.07.054