methyl [trans-4-({(3R)-1-[5-(5-fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl}oxy)cyclohexyl]acetate

Base Information

Chemical Name:methyl [trans-4-({(3R)-1-[5-(5-fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl}oxy)cyclohexyl]acetate
CAS No.:1415573-79-3
Molecular Formula:C₂₅H₂₉FN₄O₃
Molecular Weight:452.529
Hs Code.:

Synonyms:methyl [trans-4-({(3R)-1-[5-(5-fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl}oxy)cyclohexyl]acetate

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Chemical Property of methyl [trans-4-({(3R)-1-[5-(5-fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl}oxy)cyclohexyl]acetate

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Technology Process of methyl [trans-4-({(3R)-1-[5-(5-fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl}oxy)cyclohexyl]acetate

There total 14 articles about methyl [trans-4-({(3R)-1-[5-(5-fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl}oxy)cyclohexyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1415573-03-3
6-fluoro-2-(6-fluoropyridin-3-yl)-1H-benzimidazole

: 1415573-81-7
methyl {trans-4-[(3R)-pyrrolidin-3-yloxy]cyclohexyl}acetate

: 1415573-79-3
methyl [trans-4-({(3R)-1-[5-(5-fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl}oxy)cyclohexyl]acetate

Guidance literature:: With sodium hydrogencarbonate; In 1-methyl-pyrrolidin-2-one; at 110 ℃; Inert atmosphere;

Reference yield: 11.75%

: methyl [4-({1-[5-(5-fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl}oxy)cyclohexyl]acetate

: 1415573-80-6
methyl [cis-4-({1-[5-(5-fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl}oxy)cyclohexyl]acetate

: 1415573-79-3
methyl [trans-4-({(3R)-1-[5-(5-fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl}oxy)cyclohexyl]acetate

Guidance literature:: With chiralCel OD; Purification / work up; Resolution of racemate;

Reference yield:

: 66405-41-2
(4-oxo-cyclohexyl)-acetic acid methyl ester

: 1415573-79-3
methyl [trans-4-({(3R)-1-[5-(5-fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl}oxy)cyclohexyl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloro-trimethyl-silane; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

1.2: -60 - 0 °C

2.1: ChiralPak AD-H; ChiralCel OJ-H / Resolution of racemate

3.1: hydrogen / 5%-palladium/activated carbon / methanol / 760.05 Torr

4.1: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one / 110 °C / Inert atmosphere

With chloro-trimethyl-silane; hydrogen; sodium hydrogencarbonate; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol;