methyl {1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetate

Base Information

Chemical Name:methyl {1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetate
CAS No.:1033575-76-6
Molecular Formula:C₂₃H₁₉ClN₂O₅S₂
Molecular Weight:502.999
Hs Code.:

Synonyms:methyl {1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetate

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Chemical Property of methyl {1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetate

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Technology Process of methyl {1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetate

There total 4 articles about methyl {1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1033586-52-5
[5-(5-bromothiophen-2-yl)-1-(2-chlorophenyl)-1H-pyrazol-3-yloxy]acetic acid methyl ester

: 373384-18-0
3-(methanesulfonyl)phenylboronic acid

: 1033575-76-6
methyl {1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetate

Guidance literature:: With water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 70 ℃; Heating / reflux;

Reference yield:

: 5370-25-2
2-Acetyl-5-bromothiophene

: 1033575-76-6
methyl {1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran

1.2: pH 3

2.1: hydrogenchloride / methanol / 4 h / Heating / reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

4.1: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 70 °C / Heating / reflux

With hydrogenchloride; water; sodium hydride; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 4.1: Suzuki Coupling;

Reference yield:

: 1033586-51-4
5-(5-bromothiophene-2-yl)-1-(2-chlorophenyl)-1H-pyrazole-3-ol

: 1033575-76-6
methyl {1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

2: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 70 °C / Heating / reflux

With water; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Suzuki Coupling;