{1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetic acid

Base Information

Chemical Name:{1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetic acid
CAS No.:1033575-77-7
Molecular Formula:C₂₂H₁₇ClN₂O₅S₂
Molecular Weight:488.972
Hs Code.:

Synonyms:{1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetic acid

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Chemical Property of {1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetic acid

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Technology Process of {1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetic acid

There total 7 articles about {1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₁₆ClN₂O₅S₂^(1-)*Na⁽¹⁺⁾

: 1033575-77-7
{1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetic acid

Guidance literature:: With hydrogenchloride; In water;

Reference yield:

: 5370-25-2
2-Acetyl-5-bromothiophene

: 1033575-77-7
{1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran

1.2: pH 3

2.1: hydrogenchloride / methanol / 4 h / Heating / reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

4.1: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 70 °C / Heating / reflux

5.1: sodium hydroxide; water / methanol / 4 h / 20 °C

6.1: hydrogenchloride / water

With hydrogenchloride; sodium hydroxide; water; sodium hydride; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 4.1: Suzuki Coupling;

Reference yield:

: 1033586-51-4
5-(5-bromothiophene-2-yl)-1-(2-chlorophenyl)-1H-pyrazole-3-ol

: 1033575-77-7
{1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

2: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 70 °C / Heating / reflux

3: sodium hydroxide; water / methanol / 4 h / 20 °C

4: hydrogenchloride / water

With hydrogenchloride; sodium hydroxide; water; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 2: Suzuki Coupling;