(4-isopropoxy-3-methoxy-phenyl)-spiro[chromene-2,4'-piperidine]-1'-yl-methanone

Base Information

Chemical Name:(4-isopropoxy-3-methoxy-phenyl)-spiro[chromene-2,4'-piperidine]-1'-yl-methanone
CAS No.:1394030-81-9
Molecular Formula:C₂₄H₂₇NO₄
Molecular Weight:393.483
Hs Code.:

Synonyms:(4-isopropoxy-3-methoxy-phenyl)-spiro[chromene-2,4'-piperidine]-1'-yl-methanone

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Chemical Property of (4-isopropoxy-3-methoxy-phenyl)-spiro[chromene-2,4'-piperidine]-1'-yl-methanone

Chemical Property:

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Technology Process of (4-isopropoxy-3-methoxy-phenyl)-spiro[chromene-2,4'-piperidine]-1'-yl-methanone

There total 6 articles about (4-isopropoxy-3-methoxy-phenyl)-spiro[chromene-2,4'-piperidine]-1'-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1394030-80-8
(4-hydroxyspiro[chromane-2,4'-piperidine]-1'-yl)-(4-isopropoxy-3-methoxy-phenyl)methanone

: 1394030-81-9
(4-isopropoxy-3-methoxy-phenyl)-spiro[chromene-2,4'-piperidine]-1'-yl-methanone

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; at 90 ℃; for 2h;

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1394030-81-9
(4-isopropoxy-3-methoxy-phenyl)-spiro[chromene-2,4'-piperidine]-1'-yl-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: pyrrolidine / methanol / 20 h / 80 °C

2: hydrogen / palladium 10% on activated carbon / isopropyl alcohol / 25 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

4: ethanol; sodium tetrahydroborate / 6 h / 20 °C

5: toluene-4-sulfonic acid / 1,4-dioxane / 2 h / 90 °C

With pyrrolidine; sodium tetrahydroborate; ethanol; hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; isopropyl alcohol;

Reference yield:

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 1394030-81-9
(4-isopropoxy-3-methoxy-phenyl)-spiro[chromene-2,4'-piperidine]-1'-yl-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: pyrrolidine / methanol / 20 h / 80 °C

2: hydrogen / palladium 10% on activated carbon / isopropyl alcohol / 25 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

4: ethanol; sodium tetrahydroborate / 6 h / 20 °C

5: toluene-4-sulfonic acid / 1,4-dioxane / 2 h / 90 °C

With pyrrolidine; sodium tetrahydroborate; ethanol; hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; isopropyl alcohol;