8-(2-methoxycarbonyl-ethyl)-5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid prop-2-ynyl ester

Base Information

Chemical Name:8-(2-methoxycarbonyl-ethyl)-5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid prop-2-ynyl ester
CAS No.:918411-15-1
Molecular Formula:C₂₉H₃₀N₂O₆
Molecular Weight:502.567
Hs Code.:

8-(2-methoxycarbonyl-ethyl)-5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-3,4-dihydro-1<i>H</i>-isoquinoline-2-carboxylic acid prop-2-ynyl ester

Synonyms:8-(2-methoxycarbonyl-ethyl)-5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid prop-2-ynyl ester

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Chemical Property of 8-(2-methoxycarbonyl-ethyl)-5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid prop-2-ynyl ester

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Technology Process of 8-(2-methoxycarbonyl-ethyl)-5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid prop-2-ynyl ester

There total 9 articles about 8-(2-methoxycarbonyl-ethyl)-5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 918411-13-9
methyl 3-{5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-1,2,3,4-tetrahydro-isoquinolin-8-yl}-propionate

: 35718-08-2
propargyl chloroformate

: 918411-15-1
8-(2-methoxycarbonyl-ethyl)-5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid prop-2-ynyl ester

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2006.09.028

Reference yield:

: 497068-68-5
tert-butyl 8-bromo-5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 918411-15-1
8-(2-methoxycarbonyl-ethyl)-5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid prop-2-ynyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / acetone

2: Pd(OAc)2 / various solvent(s)

3: H₂ / Pd/C / ethanol

4: Cs₂CO₃ / dimethylformamide

5: CF₃CO₂H

6: Et₃N / CH₂Cl₂

With palladium diacetate; hydrogen; potassium carbonate; caesium carbonate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; 2: Heck coupling;
DOI:10.1016/j.bmcl.2006.09.028

Reference yield:

: 853074-91-6
tert-butyl 5-(benzyloxy)-8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 918411-15-1
8-(2-methoxycarbonyl-ethyl)-5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid prop-2-ynyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Pd(OAc)2 / various solvent(s)

2: H₂ / Pd/C / ethanol

3: Cs₂CO₃ / dimethylformamide

4: CF₃CO₂H

5: Et₃N / CH₂Cl₂

With palladium diacetate; hydrogen; caesium carbonate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Heck coupling;
DOI:10.1016/j.bmcl.2006.09.028