2,6-dimethoxy-4-(2-phenylthiazole-4-carbonyl)phenyl 2,2,2-trifluoroacetate

Base Information

Chemical Name:2,6-dimethoxy-4-(2-phenylthiazole-4-carbonyl)phenyl 2,2,2-trifluoroacetate
CAS No.:1332881-49-8
Molecular Formula:C₂₀H₁₄F₃NO₅S
Molecular Weight:437.396
Hs Code.:

Synonyms:2,6-dimethoxy-4-(2-phenylthiazole-4-carbonyl)phenyl 2,2,2-trifluoroacetate

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Chemical Property of 2,6-dimethoxy-4-(2-phenylthiazole-4-carbonyl)phenyl 2,2,2-trifluoroacetate

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Technology Process of 2,6-dimethoxy-4-(2-phenylthiazole-4-carbonyl)phenyl 2,2,2-trifluoroacetate

There total 5 articles about 2,6-dimethoxy-4-(2-phenylthiazole-4-carbonyl)phenyl 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.2%

: 1332881-54-5
(4-hydroxy-3,5-dimethoxyphenyl)(2-phenylthiazol-4-yl)methanone

: 407-25-0
trifluoroacetic anhydride

: 1332881-49-8
2,6-dimethoxy-4-(2-phenylthiazole-4-carbonyl)phenyl 2,2,2-trifluoroacetate

Guidance literature:: With dmap; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm500764v

Reference yield:

: 1135797-91-9
(2-phenylthiazol-4-yl)-(3,4,5-trimethoxyphenyl)methanone

: 1332881-49-8
2,6-dimethoxy-4-(2-phenylthiazole-4-carbonyl)phenyl 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum (III) chloride; water / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: dmap / dichloromethane / 0 - 20 °C

With dmap; aluminum (III) chloride; water; In dichloromethane;
DOI:10.1021/jm500764v

Reference yield:

: 1135797-67-9
2-phenyl-4,5-dihydrothiazole-4-carboxylic acid N-(methoxy)methylamide

: 1332881-49-8
2,6-dimethoxy-4-(2-phenylthiazole-4-carbonyl)phenyl 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene

2: n-butyllithium / tetrahydrofuran / -78 °C

3: aluminum (III) chloride; water / dichloromethane / 12 h / 20 °C / Inert atmosphere

4: dmap / dichloromethane / 0 - 20 °C

With dmap; aluminum (III) chloride; n-butyllithium; Bromotrichloromethane; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm500764v