Acetic acid (2S,4aR,5S,6R,8R,8aS)-6-methoxy-2-phenyl-5-(toluene-4-sulfonyl)-hexahydro-pyrano[3,4-d][1,3]dioxin-8-ylmethyl ester

Base Information

• Chemical Name: Acetic acid (2S,4aR,5S,6R,8R,8aS)-6-methoxy-2-phenyl-5-(toluene-4-sulfonyl)-hexahydro-pyrano[3,4-d][1,3]dioxin-8-ylmethyl ester
• CAS No.: 502635-91-8
• Molecular Formula: C₂₄H₂₈O₈S
• Molecular Weight: 476.548
• Mol file: 502635-91-8.mol

Synonyms:Acetic acid (2S,4aR,5S,6R,8R,8aS)-6-methoxy-2-phenyl-5-(toluene-4-sulfonyl)-hexahydro-pyrano[3,4-d][1,3]dioxin-8-ylmethyl ester

Chemical Property of Acetic acid (2S,4aR,5S,6R,8R,8aS)-6-methoxy-2-phenyl-5-(toluene-4-sulfonyl)-hexahydro-pyrano[3,4-d][1,3]dioxin-8-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (2S,4aR,5S,6R,8R,8aS)-6-methoxy-2-phenyl-5-(toluene-4-sulfonyl)-hexahydro-pyrano[3,4-d][1,3]dioxin-8-ylmethyl ester

There total 7 articles about Acetic acid (2S,4aR,5S,6R,8R,8aS)-6-methoxy-2-phenyl-5-(toluene-4-sulfonyl)-hexahydro-pyrano[3,4-d][1,3]dioxin-8-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetyl chloride (75-36-5) + [(2S,4aR,5S,6R,8R,8aS)-6-Methoxy-2-phenyl-5-(toluene-4-sulfonyl)-hexahydro-pyrano[3,4-d][1,3]dioxin-8-yl]-methanol (502635-97-4) → Acetic acid (2S,4aR,5S,6R,8R,8aS)-6-methoxy-2-phenyl-5-(toluene-4-sulfonyl)-hexahydro-pyrano[3,4-d][1,3]dioxin-8-ylmethyl ester (502635-91-8)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/S0008-6215(02)00231-8

Reference yield:

benzaldehyde dimethyl acetal (1125-88-8) → Acetic acid (2S,4aR,5S,6R,8R,8aS)-6-methoxy-2-phenyl-5-(toluene-4-sulfonyl)-hexahydro-pyrano[3,4-d][1,3]dioxin-8-ylmethyl ester (502635-91-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / TsOH / dimethylformamide / 60 °C / pH 2

2: pyridine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; toluene-4-sulfonic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0008-6215(02)00231-8

Reference yield:

methyl 2,3-dideoxy-2,3-C-hydroxymethyl-2-C-p-tolylsulfonyl-β-D-altropyranoside (502635-93-0) → Acetic acid (2S,4aR,5S,6R,8R,8aS)-6-methoxy-2-phenyl-5-(toluene-4-sulfonyl)-hexahydro-pyrano[3,4-d][1,3]dioxin-8-ylmethyl ester (502635-91-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / TsOH / dimethylformamide / 60 °C / pH 2

2: pyridine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; toluene-4-sulfonic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0008-6215(02)00231-8

upstream raw materials:

acetyl chloride

[(2S,4aR,5S,6R,8R,8aS)-6-Methoxy-2-phenyl-5-(toluene-4-sulfonyl)-hexahydro-pyrano[3,4-d][1,3]dioxin-8-yl]-methanol

benzaldehyde dimethyl acetal

methyl 2,3-dideoxy-2,3-C-hydroxymethyl-2-C-p-tolylsulfonyl-β-D-altropyranoside