(+/-)-1-[4-(tert-butyldiphenylsilyloxymethyl)-2H,5H-dihydrothiophen-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:(+/-)-1-[4-(tert-butyldiphenylsilyloxymethyl)-2H,5H-dihydrothiophen-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:328386-39-6
Molecular Formula:C₂₆H₃₀N₂O₃SSi
Molecular Weight:478.687
Hs Code.:

Synonyms:(+/-)-1-[4-(tert-butyldiphenylsilyloxymethyl)-2H,5H-dihydrothiophen-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of (+/-)-1-[4-(tert-butyldiphenylsilyloxymethyl)-2H,5H-dihydrothiophen-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of (+/-)-1-[4-(tert-butyldiphenylsilyloxymethyl)-2H,5H-dihydrothiophen-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

There total 15 articles about (+/-)-1-[4-(tert-butyldiphenylsilyloxymethyl)-2H,5H-dihydrothiophen-2-yl]-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 381211-64-9
(+/-)-1-[4-(tert-butyldiphenylsilyloxymethyl)-3-phenylselenyltetrahydrothiophen-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 328386-39-6
(+/-)-1-[4-(tert-butyldiphenylsilyloxymethyl)-2H,5H-dihydrothiophen-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -25 ℃; for 1h;
DOI:10.1021/jm000342f

Reference yield:

: 80904-75-2
4-hydroxymethyl-5H-furan-2-one

: 328386-39-6
(+/-)-1-[4-(tert-butyldiphenylsilyloxymethyl)-2H,5H-dihydrothiophen-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 14 steps

1: 99 percent / H₂ / Pd/C

2: aq. NaOH

3: aq. NaOH

4: dicyclohexylcarbodiimide

5: LiHMDS

6: -78 °C

7: DIBAL

8: trimethylsilyl trifluoromethanesulfonate

9: mCPBA

With sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; hydrogen; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; palladium on activated charcoal;
DOI:10.1081/NCN-100002344

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 328386-39-6
(+/-)-1-[4-(tert-butyldiphenylsilyloxymethyl)-2H,5H-dihydrothiophen-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 14 steps

1: 99 percent / H₂ / Pd/C

2: aq. NaOH

3: aq. NaOH

4: dicyclohexylcarbodiimide

5: LiHMDS

6: -78 °C

7: DIBAL

8: trimethylsilyl trifluoromethanesulfonate

9: mCPBA

With sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; hydrogen; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; palladium on activated charcoal;
DOI:10.1081/NCN-100002344