80904-75-2

Basic information

• Product Name: 4-HydroxyMethyl-5H-furan-2-one
• Synonyms: 4-HydroxyMethyl-5H-furan-2-one;4-(HydroxyMethyl)-2(5H)-furanone
• CAS NO: 80904-75-2
• Molecular Formula: C₅H₆O₃
• Molecular Weight: 114.09934
• Mol File: 80904-75-2.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 350.9°C at 760 mmHg
• Flash Point: 175.6°C
• Appearance: /
• Density: 1.324g/cm³
• Vapor Pressure: 2.53E-06mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: 4-HydroxyMethyl-5H-furan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HydroxyMethyl-5H-furan-2-one(80904-75-2)
• EPA Substance Registry System: 4-HydroxyMethyl-5H-furan-2-one(80904-75-2)

Safety Data

• Hazardous Substances Data: 80904-75-2(Hazardous Substances Data)

Usage

Uses

4-Hydroxymethylfuran-2(5H)-one is a monocyclic lactone isolated from the leaves of siphonside australe.

InChI:InChI=1/C5H6O3/c6-2-4-1-5(7)8-3-4/h1,6H,2-3H2

Upstream product

• 1333378-95-2 C₉H₁₆O₄ 
• 96-26-4 dihydroxyacetone 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 75887-43-3 4-bromo-3-(bromomethyl)but-2-enoic acid 
• 541-47-9 3-Methylbutenoic acid 
• 97-65-4 2-methylenesuccinic acid 
• 61934-55-2 3-bromomethyl-2-butenolide 
• 205043-35-2 4-(tert-butyldimethylsilanyloxy)-3-(tert-butyldimethylsilanyloxymethyl)but-2-enoic acid ethyl ester 
• 174655-88-0 5-oxo-2,5-dihydrofuran-3-carboxylic acid 
• 77356-33-3 4-acetoxy-3-acetoxymethyl-but-2-enoic acid ethyl ester 
• 201230-82-2 carbon monoxide 
• 107-19-7 propargyl alcohol 
• 81189-55-1 acetic acid 5-oxo-2,5-dihydrofuran-3-ylmethyl ester 

Downstream Products

• 56014-76-7 5-Chloro-4-methyl-2(5H)-furanone 
• 125973-99-1 4-(Chloromethyl)-2(5H)-furanone 
• 125973-97-9 4-formylfuran-1(5H)-one 
• 122551-89-7 3-Chloro-4-(dichloromethyl)-2(5H)-furanone 
• 212776-53-9 4-(tert-Butyl-diphenyl-silanyloxymethyl)-5H-furan-2-one 
• 81189-55-1 acetic acid 5-oxo-2,5-dihydrofuran-3-ylmethyl ester 
• 89858-76-4 (benzyloxy)-(3-furyl)methane 
• 190896-38-9 (E)-2-Benzyloxymethyl-but-2-ene-1,4-diol 
• 190896-36-7 ((2S,3S)-3-Benzyloxymethyl-3-vinyl-oxiranyl)-methanol 
• 190896-54-9 (E)-2-Benzyloxymethyl-4-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-but-2-en-1-ol 
• 190896-55-0 (Z)-3-Benzyloxymethyl-4-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-but-2-en-1-ol 
• 190896-65-2 (2S,3S)-3-Benzyloxymethyl-4-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2-methyl-butane-1,3-diol 
• 190896-37-8 {(2R,3S)-3-Benzyloxymethyl-3-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-oxiranyl}-methanol 
• 190896-56-1 {(2S,3S)-2-Benzyloxymethyl-3-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-oxiranyl}-methanol 

Relevant articles and documents

Photochemical reactions of prop-2-enyl and prop-2-ynyl substituted 4-aminomethyl- and 4-oxymethyl-2(5H)-furanones

Compounds with a heterocyclic 9-oxatricyclo[5.3.0.01,5]decan-8-one skeleton were synthesized by intramolecular [2+2] photocycloaddition reactions of the title compounds (λ= 254 nm, Et2O or MeCN as the solvent). Starting from various substituted 4-(prop-2-enylaminomethyl)-2(5H)-furanones, products 5, 9, 18, 21, 23, 24 were obtained, which bear a nitrogen atom in position 3 of this skeleton within a pyrrolidine ring. The Boc or Cbz groups represent suitable nitrogen protecting groups, which were compatible with the irradiation conditions and which can be easily cleaved. In an analogous fashion an oxygen (product 22) and carbon substituent (product 25) could be implemented at position 3 of the product if the starting material was appropriately chosen. The prop-2-ynyl substituted substrates did not produce a [2+2] photocycloaddition product but rather underwent a cyclization to spiro products 11 and 13.

TRICYCLIC COMPOUNDS

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Conformationally restricted pyrrolidines by intramolecular [2+2] photocycloaddition reactions

Intramolecular [2+2] photocycloaddition reactions of diversely substituted N-Boc protected 4-(allylaminomethyl)-2(5H)-furanones resulted in rigid products (53-75%) with three spatially defined positions for further functionalisation. The Royal Society of Chemistry.