7-[(R)-2-Benzyloxy-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-propoxy]-heptanoic acid benzyl ester

Base Information

Chemical Name:7-[(R)-2-Benzyloxy-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-propoxy]-heptanoic acid benzyl ester
CAS No.:139141-36-9
Molecular Formula:C₃₄H₃₉F₃O₇
Molecular Weight:616.675
Hs Code.:

Synonyms:7-[(R)-2-Benzyloxy-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-propoxy]-heptanoic acid benzyl ester

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Chemical Property of 7-[(R)-2-Benzyloxy-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-propoxy]-heptanoic acid benzyl ester

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Technology Process of 7-[(R)-2-Benzyloxy-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-propoxy]-heptanoic acid benzyl ester

There total 20 articles about 7-[(R)-2-Benzyloxy-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-propoxy]-heptanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 139141-23-4
1-O-<6-(Benzyloxycarbonyl)hexyl>-2-O-benzyl-sn-glycerol

: 139141-36-9
7-[(R)-2-Benzyloxy-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-propoxy]-heptanoic acid benzyl ester

Guidance literature:: With pyridine; In chloroform; for 4h; Ambient temperature;
DOI:10.1016/S0040-4020(01)96051-X

Reference yield: 90.0%

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 138594-35-1
1-O-<6-(Benzyloxycarbonyl)hexyl>-2-O-benzylglycerol

: 139141-36-9,139141-37-0
7-[2-Benzyloxy-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-propoxy]-heptanoic acid benzyl ester

Guidance literature:: With pyridine; In chloroform; for 4h; Ambient temperature;
DOI:10.1016/S0040-4020(01)96051-X

Reference yield:

: 29823-18-5
ethyl 7-bromoheptanoate

: 139141-36-9,139141-37-0
7-[2-Benzyloxy-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-propoxy]-heptanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1) NaH / 1) DMF, rt, 2) DMF, rt

2: 1.6 M NaOH / dioxane / Ambient temperature

3: NaHCO₃ / dimethylformamide / 40 °C

4: 2 M HCl / tetrahydrofuran / Ambient temperature

5: pyridine / Ambient temperature

6: 1) NaH, 2) BuN₄I / 1) DMF, rt, 2) DMF, rt

7: 1 M HCl / dioxane / 80 °C

8: 90 percent / pyridine / CHCl₃ / 4 h / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)96051-X