N-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(3-trifluoromethylthiobenzoylamino)-benzamide

Base Information

Chemical Name:N-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(3-trifluoromethylthiobenzoylamino)-benzamide
CAS No.:1616664-57-3
Molecular Formula:C₂₄H₁₇F₃N₄O₂S
Molecular Weight:482.486
Hs Code.:

Synonyms:N-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(3-trifluoromethylthiobenzoylamino)-benzamide

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Chemical Property of N-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(3-trifluoromethylthiobenzoylamino)-benzamide

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Technology Process of N-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(3-trifluoromethylthiobenzoylamino)-benzamide

There total 6 articles about N-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(3-trifluoromethylthiobenzoylamino)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1186502-34-0
1-(5-amino-1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanone

: 1616665-06-5
3-(3-trifluoromethylthiobenzoylamino)-benzoic acid

: 1616664-57-3
N-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(3-trifluoromethylthiobenzoylamino)-benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1186502-33-9
C₉H₇N₃O₃

: 1616664-57-3
N-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(3-trifluoromethylthiobenzoylamino)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 26252.6 Torr

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 87360-24-5
3-amino-benzoic acid methyl ester hydrochloride

: 1616664-57-3
N-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(3-trifluoromethylthiobenzoylamino)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2: Lawessons reagent / toluene / 3 h / 110 °C

3: water / Alkaline conditions; Reflux

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With Lawessons reagent; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; toluene;