87360-24-5

Usage

Chemical Properties

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Upstream product

• 67-56-1 methanol 
• 99-05-8 meta-aminobenzoic acid 

Downstream Products

• 16606-00-1 methyl 3-phenylbenzoate 
• 729-01-1 4'-nitrobiphenyl-3-carboxylic acid 
• 269070-07-7 3-{[5-(2-Adamantan-1-yl-ethyl)-1-benzyl-2-o-tolyl-1H-imidazole-4-carbonyl]-amino}-benzoic Acid 
• 1373998-62-9 C₂₇H₃₄N₂O₄ 
• 1425426-73-8 C₂₆H₂₄N₂O₅ 
• 1425426-75-0 C₁₇H₂₁N₃O₅ 
• 1425426-77-2 C₁₆H₂₂N₂O₅ 
• 1489279-14-2 (S)-methyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxamido)benzoate 
• 1489277-73-7 (S)-methyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)thiazole-4-carboxamido)benzoate 
• 1616665-01-0 3-(3-trifluoromethylthiobenzoylamino)-benzoic acid methyl ester 
• 1616665-06-5 3-(3-trifluoromethylthiobenzoylamino)-benzoic acid 
• 1616664-57-3 N-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(3-trifluoromethylthiobenzoylamino)-benzamide 
• 724431-28-1 3-(3-trifluoromethylbenzoylamino)-benzoic acid methyl ester 
• 93066-93-4 methyl 3-azidobenzoate 

Relevant academic research and scientific papers

Investigating Bicyclobutane-Triazolinedione Cycloadditions as a Tool for Peptide Modification

Acyl bicyclobutanes are shown to engage in strain-promoted cycloaddition reactions with a diverse array of triazolinedione reagents. The synthesis of an orthogonally protected urazole building block enabled the facile preparation of amino acid- and peptid

VEGFR-2 inhibitor and preparation method thereof

The invention provides a compound I used as a VEGFR-2 inhibitor, a preparation method thereof, and an application of the compound I in the preparation of medicines for treating persistent vasculature induced diseases.

Triazolo-β-aza-ε-amino acid and its aromatic analogue as novel scaffolds for β-turn peptidomimetics

Triazolo-β-aza-ε-amino acid and its aromatic analogue (AlTAA/ArTAA) in the peptide backbone mark a novel class of conformationally constrained molecular scaffolds to induce β-turn conformations. This was demonstrated forAlTAA in a Leu-enkephalin analogue and in a designed pentapeptide wherein the FRET process was established. Restricted rotation induced chirality and turn conformation into the achiral aromatic amino acid scaffold,ArTAA, which in a short tripeptide backbone acted as a β-turn mimic as a β-sheet folding nucleator. This journal is

Conformational studies of γ-turn in pseudopeptides containing α-amino acid and conformationally constrained meta amino benzoic acid/meta nitro aniline

Reverse turns (commonly β-turns and γ-turns), a common motif in proteins and peptides, have attracted attention due to their relevance in a wide variety of biological processes. In an attempt to artificially imitate and stabilize these turns in short acyc

A convenient synthesis of amino acid methyl esters

A series of amino acid methyl ester hydrochlorides were prepared in good to excellent yields by the room temperature reaction of amino acids with methanol in the presence of trimethylchlorosilane. This method is not only compatible with natural amino acids, but also with other aromatic and aliphatic amino acids.

PEPTIDIC COMPOUNDS

The present invention provides a compound of formula (I), (II), (III) and (IV) as defined herein and pharmaceutically acceptable derivatives thereof. The present invention further provides use of the compounds of the present invention in the treatment of bacterial infection and in the treatment of HIV infection. Also provided are pharmaceutical compositions comprising the compounds of the present invention.

Organosilicon synthesis of isocyanates: III. Synthesis of aliphatic, carbocyclic, aromatic, and alkylaromatic isocyanatocatboxylic acid esters

A series of aminoacid esters was prepared by treating the aminoacid suspensions in ethanol with thionyl chloride. Best conversion of aminoacid esters to corresponding isocyanates was achieved in the case of aromatic and carbocyclic aminoesters by phosgeneation of their N-silyl derivatives, and in the case of aliphatic and alkylaromatic aminoesters by phosgeneation of O-silyl or N,O-bissilylurethanes on their basis. In the last case additional step of esterification of the by-products isocyanatoalkylcarboxylic acid chlorides is required after phosgeneation. Unusual generation of cynnamates and intramolecular N→O-migration of trimethylsilyl group in the solutions of silylated alkylaromatic β-aminoacid esters were found. Pleiades Publishing, Inc., 2006.

PHOSPHONATE AND PHOSPHONAMIDE ENDOPEPTIDASE INHIBITORS

Compounds of the formula STR1 wherein Y is O or NH and X is STR2 will inhibit the action of neutral endopeptidase. As a result, such compounds produce diuresis, natriuresis, and lower blood pressure as well as being useful in the treatment of congestive heart failure, relieving pain, and diarrhea when administered to a mammalian host.

Aminobenzoic and aminocyclohexanecarboylic acid compounds, compositions, and their method of use

Compounds of the formula inhibit the action of neutral endopeptidase. As a result, such compounds produce diuresis, natriuresis, and lower blood pressure as well as being useful in the treatment of congestive heart failure, relieving pain, and diarrhea when administered to a mammalian host.

Cyclohexyl and phenyl substituted enkephalins

The invention discloses cyclohexyl and phenyl substituted enkephalin derivatives of the formula: STR1 Where R1, R2, R4, and R8 is hydrogen or alkyl of R3 is alkylthioalkyl or alkylsulfinylalkyl, X is: