1-[4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethanone

Base Information

• Chemical Name: 1-[4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethanone
• CAS No.: 863881-19-0
• Molecular Formula: C₁₇H₁₄BrNO₃S
• Molecular Weight: 392.273
• Mol file: 863881-19-0.mol

Synonyms:1-[4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethanone

Chemical Property of 1-[4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethanone

There total 4 articles about 1-[4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-bromo-1H-indol-3-yl)ethan-1-one (195874-03-4) + p-toluenesulfonyl chloride (98-59-9) → 1-[4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethanone (863881-19-0)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1021/ol051043t

Reference yield:

4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indole (90481-72-4) + acetic anhydride (108-24-7) → 1-[4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethanone (863881-19-0)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1002/jhet.5570440407

Reference yield:

4-bromo-1H-indole (52488-36-5) → 1-[4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethanone (863881-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / SnCl₄ / toluene / 2 h / 0 °C

2: 100 percent / (i-Pr)2NEt; DMAP / CH₂Cl₂ / 20 h / 20 °C

With dmap; tin(IV) chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; 1: Friedel-Crafts reaction;

DOI:10.1021/ol051043t

upstream raw materials:

1-(4-bromo-1H-indol-3-yl)ethan-1-one

p-toluenesulfonyl chloride

4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indole

acetic anhydride

Downstream raw materials:

2-(4-bromo-1-tosyl-1H-indol-3-yl)propan-2-ol

4-bromo-3-acetyl-1-methyl-1H-indole

2-(2-(4-bromo-1-methyl-1H-indol-3-yl)propan-2-yl)cyclohexanone

2-(2-(4-bromo-1H-indol-3-yl)propan-2-yl)cyclohexanone