ethyl 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate

Base Information

Chemical Name:ethyl 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate
CAS No.:130227-94-0
Molecular Formula:C₂₅H₂₇N₅O₂
Molecular Weight:429.522
Hs Code.:

Synonyms:ethyl 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate

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Chemical Property of ethyl 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate

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Technology Process of ethyl 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate

There total 9 articles about ethyl 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3099-31-8
nicotinyl chloride

: 128972-12-3
ethyl (8-isobutyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazin-3-yl)acetate

: 130227-94-0
ethyl 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 0 deg C, 2.) 2 h;
DOI:10.1021/jm00171a005

Reference yield:

: 6959-48-4
3-chloromethylpyridinium chloride

: 128972-12-3
ethyl (8-isobutyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazin-3-yl)acetate

: 130227-94-0
ethyl 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate

Guidance literature:: With hydrogenchloride; sodium bicarbonate; sodium chloride; In N,N-dimethyl-formamide;

Reference yield:

: 5468-37-1
2-aminoacetophenone hydrochloride

: 130227-94-0
ethyl 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) 1,3-dicyclohexylcarbodiimide (DCC), 2.) 1-hydroxybenzotriazole hydrate (HOBT) / CH₂Cl₂

2: 67 percent / ammonium acetate / ethanol / 3.5 h / Heating

3: COCl₂ / toluene; tetrahydrofuran / 4 h / Heating

4: 45 percent / H₂N-NH₂*H₂O / dimethylsulfoxide / 2 h / Heating

5: 52 percent / ethyl acetate / 1 h / 0 °C

6: 74 percent / p-toluenesulfonic acid monohydrate (PTSA) / toluene / 2.5 h / Heating

7: 1.) NaH / 1.) DMF, 0 deg C, 2.) 2 h

With ammonium acetate; sodium hydride; toluene-4-sulfonic acid; hydrazine hydrate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1021/jm00171a005