N-(tert-butyloxycarbonylmethylcarbonyl) α-(9-fluorenylmethyl) β-cyclohexyl L-aspartate

Base Information

• Chemical Name: N-(tert-butyloxycarbonylmethylcarbonyl) α-(9-fluorenylmethyl) β-cyclohexyl L-aspartate
• CAS No.: 446880-42-8
• Molecular Formula: C₃₁H₃₇NO₇
• Molecular Weight: 535.637
• Mol file: 446880-42-8.mol

Synonyms:N-(tert-butyloxycarbonylmethylcarbonyl) α-(9-fluorenylmethyl) β-cyclohexyl L-aspartate

Chemical Property of N-(tert-butyloxycarbonylmethylcarbonyl) α-(9-fluorenylmethyl) β-cyclohexyl L-aspartate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butyloxycarbonylmethylcarbonyl) α-(9-fluorenylmethyl) β-cyclohexyl L-aspartate

There total 1 articles about N-(tert-butyloxycarbonylmethylcarbonyl) α-(9-fluorenylmethyl) β-cyclohexyl L-aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

mono-tert-butyl malonate (40052-13-9) + 1-α-(9-fluorenylmethyl)-β-cyclohexyl-aspartate hydrochloride → N-(tert-butyloxycarbonylmethylcarbonyl) α-(9-fluorenylmethyl) β-cyclohexyl L-aspartate (446880-42-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/jo011041w

Reference yield:

N-(tert-butyloxycarbonylmethylcarbonyl) α-(9-fluorenylmethyl) β-cyclohexyl L-aspartate (446880-42-8) → N-(carboxymethylcarbonyl) α-(9-fluorenylmethyl) β-cyclohexyl L-aspartate (330187-49-0)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃;

DOI:10.1021/jo011041w

Reference yield:

N-(tert-butyloxycarbonylmethylcarbonyl) α-(9-fluorenylmethyl) β-cyclohexyl L-aspartate (446880-42-8) → 2-{2-[{2-[tert-butoxycarbonylmethyl-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-ethyl}-(1-carbamoyl-2-phenyl-ethyl)-carbamoyl]-acetylamino}-succinic acid 4-cyclohexyl ester 1-(9H-fluoren-9-ylmethyl) ester

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / diethyl ether / 20 °C

2: HATU; diisopropylethylamine / dimethylformamide / 4 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/jo011041w

upstream raw materials:

mono-tert-butyl malonate

Downstream raw materials:

N-(carboxymethylcarbonyl) α-(9-fluorenylmethyl) β-cyclohexyl L-aspartate