3-[4-(4-methyl-piperazin-1-yl)-phenylamino]-5-phenylamino-pyridine-2-carbonitrile

Base Information

Chemical Name:3-[4-(4-methyl-piperazin-1-yl)-phenylamino]-5-phenylamino-pyridine-2-carbonitrile
CAS No.:1389441-00-2
Molecular Formula:C₂₃H₂₄N₆
Molecular Weight:384.484
Hs Code.:

Synonyms:3-[4-(4-methyl-piperazin-1-yl)-phenylamino]-5-phenylamino-pyridine-2-carbonitrile

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Chemical Property of 3-[4-(4-methyl-piperazin-1-yl)-phenylamino]-5-phenylamino-pyridine-2-carbonitrile

Chemical Property:

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Technology Process of 3-[4-(4-methyl-piperazin-1-yl)-phenylamino]-5-phenylamino-pyridine-2-carbonitrile

There total 3 articles about 3-[4-(4-methyl-piperazin-1-yl)-phenylamino]-5-phenylamino-pyridine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1389440-99-6
5-bromo-3-(4-(4-methylpiperazin-1-yl)phenylamino)picolinonitrile

: 62-53-3
aniline

: 1389441-00-2
3-[4-(4-methyl-piperazin-1-yl)-phenylamino]-5-phenylamino-pyridine-2-carbonitrile

Guidance literature:: With caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 110 ℃; for 3h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 573675-25-9
5-bromo-3-nitropyridine-2-carbonitrile

: 1389441-00-2
3-[4-(4-methyl-piperazin-1-yl)-phenylamino]-5-phenylamino-pyridine-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / -25 - 20 °C

2: triethylamine / isopropyl alcohol / Microwave irradiation

3: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 3 h / 110 °C / Microwave irradiation; Inert atmosphere

With tetrabutyl ammonium fluoride; caesium carbonate; triethylamine; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; isopropyl alcohol; toluene;

Reference yield:

: 886373-28-0
5-bromo-3-fluoropyridine-2-carbonitrile

: 1389441-00-2
3-[4-(4-methyl-piperazin-1-yl)-phenylamino]-5-phenylamino-pyridine-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / isopropyl alcohol / Microwave irradiation

2: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 3 h / 110 °C / Microwave irradiation; Inert atmosphere

With caesium carbonate; triethylamine; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In isopropyl alcohol; toluene;